DR. JEFFREY P FRIEDMAN, MD
Osteopathic Medicine at 34 St, New York, NY

7619079, Nov 17, 2009

Apr 24, 2006

11/410186

Jeffrey M. Friedman - New York NY, US
Gwo-Hwa Lee - New York NY, US
Ricardo Proenca - Astoria NY, US

The Rockefeller University - New York NY

C07H 21/04, C12Q 1/68

536 2431, 536 243, 435 6

The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e. g. , to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.

2002010, Aug 8, 2002

Dec 13, 2000

09/736084

Jeffrey Friedman - New York NY, US
Jeffrey Halaas - New York NY, US
Ketan Gajiwala - New York NY, US
Stephen Burley - New York NY, US
Yiying Zhang - New York NY, US
Ricardo Proenca - Astoria NY, US
Margherita Maffei - New York NY, US

The Rockefeller University

A61K048/00, C07H021/04

514/044000, 536/023200

The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of weight, and to the diagnostic and therapeutic uses to which such modulators may be put. In its broadest aspect, the present invention relates to the elucidation and discovery of nucleotide sequences, and proteins putatively expressed by such nucleotides or degenerate variations thereof, that demonstrate the ability to participate in the control of mammalian body weight. The nucleotide sequences in object represent the genes corresponding to the murine and human ob gene, that have been postulated to play a critical role in the regulation of body weight and adiposity. Preliminary data, presented herein, suggests that the polypeptide product of the gene in question functions as a hormone. The present invention further provides nucleic acid molecules for use as molecular probes, or as primers for polymerase chain reaction (PCR) amplification, i.e., synthetic or natural oligonucleotides. In further aspects, the present invention provides a cloning vector, which comprises the nucleic acids of the invention; and a bacterial, insect, or a mammalian expression vector, which comprises the nucleic acid molecules of the invention, operatively associated with an expression control sequence. Accordingly, the invention further relates to a bacterial or a mammalian cell transfected or transformed with an appropriate expression vector, and correspondingly, to the use of the above mentioned constructs in the preparation of the modulators of the invention. Also provided are antibodies to the ob polypeptide. Moreover, a method for modulating body weight of a mammal is provided. In specific examples, genes encoding two isoforms of both the murine and human ob polypeptides are provided.

2002003, Mar 28, 2002

Sep 25, 2001

09/960995

Scitt Mager - New york NY, US
Jeffrey Friedman - New York NY, US

G06F015/16

709/217000

A system and method for managing the infrastructure and environment of a building and the provision of internal services in the building by providing a portal for a building accessible via the Internet having services associated with the portal based upon specific needs of the building. Orders for internal services are received from a user of the portal and the user is provided with status information for the orders. The portal is designed to suit the specific needs of a building.

7016817, Mar 21, 2006

Nov 14, 2002

10/294026

Harold S. Friedman - New York NY, US
Jeffrey Friedman - New York NY, US

G06F 17/50

703 1, 52 30, 187401

An Elevator cab design process for providing an attractive appearance complementary to a building in which the elevator is installed, by.