Inventors:
Chun Li - Missouri City TX, US
Wei Wang - Sugar Land TX, US
Marites P. Melancon - Houston TX, US
Juri G. Gelovani - Houston TX, US
Jeffrey Myers - Houston TX, US
International Classification:
A61K 49/06, C07D 403/10, C12Q 1/02, A61K 49/00
US Classification:
424 93, 548455, 435 29, 424 91
Abstract:
The disclosure includes a composition including a poly(L-glutamic acid) and a NIRF dye. It also includes a method including providing to a plurality of cells an imaging agent including poly(L-glutamic acid), a NIRF dye and then imaging the cells to detect the imaging agent. It further includes a dual functional contrast agent including an MRI agent conjugated with an optical imaging agent. A method of detecting cancer is provided including injecting a dual functional contrast agent into a patient and performing both an MRI and an optical scan. The presence of the agent may indicate cancer. A method of detecting cancer by injecting PG-DTPA-Gd-NIR813 into a patient, then detecting the presence or absence of Gd in a cell or tissue of the patient and detecting the presence or absence of NIR813 in a cell or tissue of the patient is provided. The presence of Gd and NIR813 may indicate cancer.