Inventors:
Clark K. Colton - Newton MA, US
Jeffrey R. Millman - Cambridge MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
A61K 35/12, C12N 5/077, C12Q 1/02, C12N 5/071
US Classification:
424 937, 435325, 435377, 435 29
Abstract:
The invention provides methods and compositions relating to differentiated cell populations that derive from pluripotent stem cells. The methods relate to reducing the number of residual stem cells present in such populations. The compositions include differentiated cell populations that contain reduced number of stem cells or that contain no stem cells. Pluripotent stem cells may be reduced in number and/or function through exposure to low oxygen levels.