DR. JEFFREY MICHAEL FRIEDMAN, M.D.
Hospitals at York Ave, New York, NY

2002015, Oct 17, 2002

Jul 12, 2001

09/904117

Tom Muir - New York NY, US
Philip Cole - New York NY, US
Jeffrey Friedman - New York NY, US
Dolan Sondhi - New York NY, US
Konstantine Severinov - New York NY, US

C12N009/00, C07K014/00

435/183000, 530/334000

The present invention provides a method of cleaving a recombinantly expressed protein from an intein and ligating the protein to a peptide containing an N-terminal cysteine having an unoxidized sulfhydryl side chain which comprises contacting the protein with the peptide in a reaction solution comprising a conjugated thiophenol, thereby forming a C-terminal thioester of the recombinant protein which spontaneously rearranges intramolecularly to form an amide bond linking the protein to the peptide. The present invention also provides a method of producing a protein-chip composition comprising the steps of: (a) contacting a solid support chip containing an amine group with a peptide containing an N-terminal cysteine having an unoxidized sulfhydryl side chain thereby covalently linking the peptide to the solid support, forming a peptide-chip; and (b) contacting a recombinant protein having an intein domain with the peptide-chip of step (a) with a reaction solution containing a conjugated thiophenol, thereby forming a C-terminal thioester of the recombinant protein which spontaneously rearranges intramoleculaly to form an amide bond covalently linking the protein to the peptide-chip, thereby producing a protein-chip composition.

6124448, Sep 26, 2000

Jun 7, 1995

8/488208

Jeffrey M. Friedman - New York NY
Yiying Zhang - New York NY
Ricardo Proenca - Astoria NY
Margherita Maffei - New York NY

The Rockfeller University - NY

C12N 1512, C12Q 168

536 243

The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of weight, and to the diagnostic and therapeutic uses to which such modulators may be put. In its broadest aspect, the present invention relates to the elucidation and discovery of nucleotide sequences, and proteins putatively expressed by such nucleotides or degenerate variations thereof, that demonstrate the ability to participate in the control of mammalian body weight. The nucleotide sequences in object represent the genes corresponding to the murine and human ob gene, that have been postulated to play a critical role in the regulation of body weight and adiposity. Preliminary data, presented herein, suggests that the polypeptide product of the gene in question functions as a hormone. The present invention further provides nucleic acid molecules for use as molecular probes, or as primers for polymerase chain reaction (PCR) amplification, i. e.

6048837, Apr 11, 2000

Jun 7, 1995

8/485942

Jeffrey M. Friedman - New York NY
Yiying Zhang - New York NY
Ricardo Proenca - Astoria NY

The Rockefeller University

A61K 3800

514 2

The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of body weight, and to diagnostic and therapeutic uses of such modulators. In its broadest aspect, the present invention relates to nucleotide sequences corresponding to the murine and human OB gene, and two isoforms thereof, and proteins expressed by such nucleotides or degenerate variations thereof, that demonstrate the ability to participate in the control of mammalian body weight and that have been postulated to play a critical role in the regulation of body weight and adiposity. The present invention further provides nucleic acid molecules for use as molecular probes or as primers for polymerase chain reaction (PCR) amplification. In further aspects, the present invention provides cloning vectors and mammalian expression vectors comprising the nucleic acid molecules of the invention. The invention further relates to host cells transfected or transformed with an appropriate expression vector and to their use in the preparation of the modulators of the invention.

5935810, Aug 10, 1999

Nov 30, 1994

8/347563

Jeffrey M. Friedman - New York NY
Yiying Zhang - New York NY
Ricardo Proenca - Astoria NY
Margherita Maffei - Asciano, IT
Jeffrey L. Halaas - New York NY
Ketan Gajiwala - New York NY
Stephen K. Burley - New York NY

The Rockefeller University - New York NY

C12N 1512, C12N 115, C12N 121, C12N 510

435 691

The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of weight, and to the diagnostic and therapeutic uses to which such modulators may be put. In its broadest aspect, the present invention relates to the elucidation and discovery of nucleotide sequences, and proteins putatively expressed by such nucleotides or degenerate variations thereof, that demonstrate the ability to participate in the control of mammalian body weight. The nucleotide sequences in object represent the genes corresponding to the murine and human ob gene, that have been postulated to play a critical role in the regulation of body weight and adiposity. Preliminary data, presented herein, suggests that the polypeptide product of the gene in question functions as a hormone. The present invention further provides nucleic acid molecules for use as molecular probes, or as primers for polymerase chain reaction (PCR) amplification, i. e.

7991591, Aug 2, 2011

Dec 3, 2007

11/999085

Harold S. Friedman - New York NY, US
Jeffrey Friedman - New York NY, US

G06F 17/50

703 1, 52 30, 187401, 434 79

A system and method of interior design is provided having an interface for displaying a design report; providing a selection of predetermined architectural designs which can be selected from the design report; wherein each of the predetermined architectural designs includes a plurality of design elements selected from the group of optional elements, non-optional elements, and selectable elements; providing a choice of at least one of the optional and selectable elements for inclusion in a selected predetermined architectural design; and determining design parameters based upon chosen optional elements, non-optional elements, and selectable elements in the selected predetermined architectural design.

7305329, Dec 4, 2007

Mar 20, 2006

11/384606

Jeffrey Friedman - New York NY, US
Harold S. Friedman - New York NY, US

G06F 17/50

703 1, 52 30, 187401

A lobby or other public space design process for providing an attractive appearance complementary to a building in which the lobby is installed, by.