JEFFREY MICHAEL BERGELSON
Medical Practice in Penn Valley, PA
License number
Pennsylvania MD063460L
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Penn Valley, PA 19072
Professional information
Car: A Novel Coxsackievirus And Adenovirus Receptor
US Patent:
6210921, Apr 3, 2001
Filed:
Sep 12, 1997
Appl. No.:
8/928383
Inventors:
Robert W. Finberg - Canton MA
Jeffrey M. Bergelson - Narberth PA
Marshall S. Horwitz - Larchmont NY
Jeffrey M. Bergelson - Narberth PA
Marshall S. Horwitz - Larchmont NY
International Classification:
C12N 1500
US Classification:
435 691
Abstract:
The invention provides isolated nucleic acid molecules which encode a coxsackievirus and adenovirus receptor protein, CAR. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing CAR nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a CAR gene has been introduced or disrupted. The invention still further provides isolated CAR proteins, fusion proteins, antigenic peptides and anti-CAR antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.