Jeffrey Lance Creech
Engineering at Ashby Ave, Los Angeles, CA

6602468, Aug 5, 2003

Dec 21, 1999

09/469261

William R. Patterson - Irvine CA
Jeffrey L. Creech - Los Angeles CA

TherOx, Inc. - Irvine CA

A61M 134

422 45, 422 44, 604 401, 604 614, 604 616, 261 29, 261DIG 27

A method for a bubble-free oxygenated blood delivery is provided. The method includes a step of selecting a delivery system having a tubular elongated member with a lumen. The selecting step comprises determining an effective diameter of the lumen needed to achieve a bubble-free delivery of the oxygenated blood based on a specified oxygenated blood flow rate and a desired target oxygen partial pressure in the oxygenated blood. The delivery system includes a generally tubular elongated member having a proximal end portion, a distal end portion, and a transition portion located between the proximal end portion and the distal end portion. The transitional portion is relatively flexible compared to the proximal end portion and is relatively stiff compared to the distal end portion. In another embodiment, the delivery system includes a generally tubular elongated member having a proximal end portion and a distal end portion with a plurality of holes.

6565807, May 20, 2003

Dec 21, 1999

09/467670

William R. Patterson - Irvine CA
Stephen E. Myrick - Tustin CA
Vincent Divino, Jr. - Mission Viejo CA
Jeffrey L. Creech - Los Angeles CA
Mark S. Buhr - Huntington Beach CA

TherOx, Inc. - Irvine CA

A61M 136

422 45, 604 613, 604 401, 128DIG 3, 261DIG 28, 4352831

An apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a gas-supersaturating fluid, e. g. , physiologic saline; a second inlet to receive a gas, e. g. , oxygen, from a gas supply; and an outlet coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet creates within the chamber fine droplets of fluid into which the gas diffuses to create the gas-supersaturated fluid, which is removed via the outlet. The removed gas-supersaturated fluid mixes with blood within a liquid-to-liquid oxygenation assembly to form oxygenated blood for delivery to a patient. Alternately, the blood may be provided by the pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen diffuses across the membrane(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site.

6759008, Jul 6, 2004

Sep 30, 1999

09/410179

William R. Patterson - Irvine CA
Jeffrey L. Creech - Los Angeles CA

Therox, Inc. - Irvine CA

A61M 136

422 45, 422 44, 604 401, 604 614, 604 616

An apparatus for blood oxygenation and delivery is provided. The apparatus advantageously comprises a liquid-to-liquid oxygenation assembly with a pressurizable chamber having inlets for a first gas-supersaturated fluid and a second fluid, such as blood. The inlets are advantageously positioned on the mixing chamber in such a way that the first fluid and the second fluid enter the mixing chamber normally to each other to promote mixing and liquid-to-liquid gas transfer. The apparatus also includes a delivery system coupled to the blood oxygenation assembly. The delivery system includes a generally tubular elongated member having a proximal end portion, a distal end portion, and a transition portion located between the proximal end portion and the distal end portion. The transitional portion is relatively flexible compared to the proximal end portion and is relatively stiff compared to the distal end portion. In another embodiment, the delivery system includes a generally tubular elongated member having a proximal end portion and a distal end portion with a plurality of holes.

6387324, May 14, 2002

Sep 30, 1999

09/409952

William R. Patterson - Irvine CA
Stephen E. Myrick - Tustin CA
Vincent Divino, Jr. - Mission Viejo CA
Jeffrey L. Creech - Los Angeles CA
Mark S. Buhr - Huntington Beach CA

TherOx, Inc. - Irvine CA

A61M 114

422 45, 422 47, 604 614, 604 616, 128DIG 3, 261 782, 261DIG 28, 210758

An apparatus and method for blood oxygenation is provided, advantageously comprising an extracorporeal circuit for the preparation and delivery of hyperoxic or hyperbaric blood. In one embodiment, an apparatus for gas-supersaturating fluids, e. g. , physiologic saline, includes a chamber having a first inlet to receive the fluid; a second inlet to receive a gas, e. g. , oxygen, from a gas supply that maintains pressure within the chamber at a predetermined level, advantageously about 600 p. s. i. ; and an outlet advantageously coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet advantageously creates within the chamber fine droplets of fluid into which gas diffuses to create the gas-supersaturated fluid, which collects within the chamber below the atomizer nozzle for removal via the outlet. The removed gas-supersaturated fluid mixes with blood provided by a blood pump, the mixing occurring within a liquid-to-liquid oxygenation assembly including a pressurizable chamber having inlets for the gas-supersaturated fluid and blood, the inlets advantageously arranged to create a vortical or cyclonic fluid flow within the chamber to promote mixing. The mixed fluid exits the chamber via an outlet for delivery to a patient (e. g.

6811750, Nov 2, 2004

Feb 8, 2002

10/071702

William R. Patterson - Irvine CA
Stephen E. Myrick - Tustin CA
Vincent Divino, Jr. - Mission Viejo CA
Jeffrey L. Creech - Los Angeles CA
Mark S. Buhr - Huntington Beach CA

TherOx, Inc. - Irvine CA

A61M 136

422 45, 604 614, 261DIG 28

Apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a fluid, e. g. , physiologic saline; a second inlet to receive a gas, e. g. , oxygen, from a gas supply; and an outlet coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet creates within the chamber fine droplets of fluid into which the gas diffuses to create a gas-supersaturated fluid, which is removed via the outlet. The removed gas-supersaturated fluid mixes with blood within a liquid-to-liquid oxygenation assembly to form oxygenated blood for delivery to a patient. Alternately, the blood may be provided by a pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen diffuses across the membrane(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site.

2013029, Nov 7, 2013

Apr 23, 2013

13/986361

Jeffrey L. Creech - Los Angeles CA, US

THEROX, INC. - Irvine CA

B01F 3/04

3661624, 261 76, 261 58, 261 361, 29428

The present invention provides a system for enriching a flowing liquid with a dissolved gas inside a conduit. The system comprises two or more capillaries, each capillary delivering a stream of a gas-enriched liquid to the flowing liquid. The first ends of the capillaries are positioned to form an intersecting angle with respect to the effluent streams such that these streams of gas-enriched liquid collide with each other upon exit from the first ends of the capillaries, effecting localized convective mixing within the larger liquid conduit before these gas-enriched streams are able to come into close contact with the boundary surfaces of the conduit, whereby the gas-enriched liquid mixes with the flowing liquid to form a gas-enriched flowing liquid. In the preferred embodiment, no observable bubbles are formed in the gas-enriched flowing liquid. Methods of making and using such system are also provided.

2013026, Oct 17, 2013

Mar 12, 2013

13/815602

Jeffrey L. Creech - Los Angeles CA, US
Terry A. Marchwick - Mission Viejo CA, US

G01N 29/02, A61M 1/36

73 1903

This invention discloses a modular system having a base module, a mid-section control module, and a display module for preparing and administering a gas-enriched bodily fluid. Gas-enrichment is achieved by a gas-enriching device which can be in the form of a disposable cartridge. During operation, the gas-enrichment device is placed in an enclosure within the control module. An electronic controller manages the various aspects of the system such as the production of gas-enriched fluid, flow rates, bubble detection, and automatic operation and shut down. The system includes a combination bubble detector/flow meter that uses a single ultrasonic probe for measuring both bubbles and fluid flow rate.

6855291, Feb 15, 2005

Mar 7, 2003

10/384301

William R. Patterson - Irvine CA, US
Stephen E. Myrick - Tustin CA, US
Vincent Divino, Jr. - Mission Viejo CA, US
Jeffrey L. Creech - Los Angeles CA, US
Mark S. Buhr - Huntington Beach CA, US

TherOx, Inc. - Irvine CA

A61M001/14, A61M037/00

422 45, 604 614, 261DIG 28

An apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a gas-supersaturating fluid, e. g. , physiologic saline; a second inlet to receive a gas, e. g. , oxygen, from a gas supply; and an outlet coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet creates within the chamber fine droplets of fluid into which the gas diffuses to create the gas-supersaturated fluid, which is removed via the outlet. The removed gas-supersaturated fluid mixes with blood within a liquid-to-liquid oxygenation assembly to form oxygenated blood for delivery to a patient. Alternately, the blood may be provided by the pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen diffuses across the membranes(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site.

7172727, Feb 6, 2007

Sep 29, 2004

10/953747

William R. Patterson - Irvine CA, US
Stephen E. Myrick - Tustin CA, US
Vincent Divino, Jr. - Mission Viejo CA, US
Jeffrey L. Creech - Los Angeles CA, US
Mark S. Buhr - Huntington Beach CA, US

TherOx, Inc. - Irvine CA

A61M 1/34, A61M 1/36, A61M 37/00

422 45, 422 44, 604 614, 261DIG 28

An apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a fluid, e. g. , physiologic saline; a second inlet to receive a gas, e. g. , oxygen, from a gas supply; and an outlet coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet creates within the chamber fine droplets of fluid into which the gas diffuses to create a gas-supersaturated fluid, which is removed via the outlet. The removed gas-supersaturated fluid mixes with blood within a liquid-to-liquid oxygenation assembly to form oxygenated blood for delivery to a patient. Alternately, the blood may be provided by a pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen diffuses across the membrane(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site.