Inventors:
Jeffrey L. Goldberg - Miami FL, US
Vance P. Lemmon - Miami FL, US
John Bixby - Miami FL, US
Darcie Moore - Zurich, CH
Murray Blackmore - Miami FL, US
Assignee:
University of Miami - Miami FL
International Classification:
A61K 49/00, A61K 38/00, A61K 38/18
Abstract:
This invention relates, to a method for promoting CNS axon regeneration, comprising (1) inhibiting the expression or activity in a neuron of one or more of the members of the Krüppel-like transcription factor (KLF) family that suppress axon growth (e. g. , KLF 1, 2, 3, 4, 5, 9,12, 13, 14, 15 and/or 16), and/or (2) stimulating the expression or activity in a neuron of one or more of the members of the KLF family that promote axon growth (e. g. , KLF 6 and/or 7).