JEFFREY K COHEN, MD
Urology at Federal St, Pittsburgh, PA

2013000, Jan 3, 2013

Jul 3, 2012

13/541171

John Maier - Pittsburgh PA, US
Jeffrey Cohen - Pittsburgh PA, US
Ryan Priore - Wexford PA, US

Chemlmage Corporation - Pittsburgh PA

G01J 3/28, G01J 3/44

356 51, 356402, 356301

The present disclosure provides for a system and method for assessing chronic exposure of a biological sample, such as a bodily fluid, to an analyte of interest. A biological sample may be illuminated to thereby generate a one or more pluralities of interacted photons. These interacted photons may be detected to thereby generate one or more spectroscopic data sets representative of a biological sample. Spectroscopic data sets generated may be compared to at least one reference data set. Each reference data set may be associated with a known exposure to a known analyte. The present disclosure contemplates that the system and method disclosed herein may be used to analyze exposure of biological samples to at least one analyte over time. Data sets may be obtained at various time intervals to assess changes in a molecular composition as a result of chronic exposure to an analyte.

7477378, Jan 13, 2009

Sep 27, 2006

11/527839

Jeffrey Cohen - Pittsburgh PA, US
John S. Maier - Pittsburgh PA, US

ChemImage Corporation - Pittsburgh PA

G01N 3/44

356301, 356326

A system and method of correlating Raman measurements with digital images of a sample so to classify the sample's disease state. A spectroscopic data set is obtained for the sample positioned in the field of view of a spectroscopic device. With the sample removed from the field of view, the sample is treated with a contrast enhancing agent. The treated sample is repositioned in the spectroscopic device's field of view and a digital image of the treated sample is obtained. The spectroscopic data set is linked with the digital image by defining a transformation to map the image spatial coordinates of the digital image to the spectral spatial coordinates of the spectroscopic data. For the spectroscopic data set of the sample, a database is searched to identify a spectroscopic data set, of a known sample having well characterized pathology, which matches the sample's spectroscopic data set.

2012006, Mar 15, 2012

Jun 6, 2011

13/153775

Shona Stewart - Pittsburgh PA, US
John Maier - Pittsburgh PA, US
Jeffrey Cohen - Pittsburgh PA, US

Chemimage Corporation - Pittsburgh PA

G01N 21/00, G01J 3/44, G01N 21/64, G01J 5/08

356 72, 2503418, 356301, 2504581

A system and method to provide a diagnosis of the breast disease state of a test breast sample. A database containing a plurality of reference SWIR data sets is provided where each reference SWIR data set has an associated known breast sample and an associated known breast disease state. A test breast sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test SWIR data set. The test SWIR data set is compared to the plurality of reference SWIR data sets using a chemometric technique. Based on the comparison, a diagnosis of a breast disease state of the test breast sample is provided. The breast disease state includes invasive ductal carcinoma or invasive lobular carcinoma disease state.

7760353, Jul 20, 2010

Oct 9, 2008

12/248344

John Maier - Pittsburgh PA, US
Jeffrey Cohen - Pittsburgh PA, US

ChemImage Corporation - Pittsburgh PA

G01J 3/44

356301

A spectroscopic method and system to identify a biofilm of a microorganism. A sample containing a sample microorganism is irradiated with substantially monochromatic radiation. A Raman data set is obtained based on radiation scattered from the irradiated sample. A database is searched in accordance with the Raman data set in order to identify a known Raman data set from the database. The database contains a plurality of known Raman data sets where each known Raman data set is associated with a known sessile form of a corresponding known microorganism. A sessile form of the sample microorganism is identified based on the known Raman data set identified by the searching.

2012031, Dec 6, 2012

Apr 19, 2012

13/450579

Shona Stewart - Pittsburgh PA, US
Arny Drauch - Carnegie PA, US
Jeffrey Cohen - Pittsburgh PA, US
John Maier - Pittsburgh PA, US

ChemImage Corporation - Pittsburgh PA

G01J 3/46, G06F 19/00, G01J 5/02

702 19, 356402, 25033907

The present disclosure provides for a system and method for analyzing biological samples to thereby provide a diagnosis. A system may comprise an illumination source, a filter and a detector configured to generate at least one of: a visible data set representative of a biological sample, a SWIR data set representative of a biological sample, and combinations thereof. A method may comprise illuminating a biological sample to generate a plurality of photons, filtering a said plurality of interacted photons, detecting