Inventors:
Robert A. Henderson - Newbury Park CA, US
Tongtong Wang - Indianapolis IN, US
Yoshihiro Watanabe - Tsuzuki-ku, JP
Michael D. Kalos - Duarte CA, US
Paul R. Sleath - Seattle WA, US
Jeffrey C. Johnson - Des Moines WA, US
Marc W. Retter - Carnation WA, US
Margarita Durham - Seattle WA, US
Darrick Carter - Seattle WA, US
Gary R. Fanger - Mill Creek WA, US
Thomas S. Vedvick - Federal Way WA, US
Chaitanya S. Bangur - Issaquah WA, US
Andria McNabb - Renton WA, US
Assignee:
CORIXA CORPORATION - Hamilton MT
International Classification:
A61K 39/395, A61K 39/00
US Classification:
4241391, 4241841, 4241921
Abstract:
Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.