JEFFREY I JOSEPH
Physician in Penn Valley, PA

5995860, Nov 30, 1999

Jul 6, 1995

8/500388

Xiaoguang Sun - King of Prussia PA
Jeffrey I. Joseph - Penn Valley PA

Thomas Jefferson University - Philadelphia PA

A61B 500, A61M 5142

600341

An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue has at least one source of radiation from infrared through visible light, arranged to direct the radiation at the tissue where it is affected by interaction with the tissue, and a plurality of detectors. Each detector has associated with it a filter transparent to a discrete narrow band of radiation, and each detector provides an output signal representative of detected radiation in that narrow band. The detectors are located with respect to the tissue to receive radiation affected by the tissue. The invention also encompasses a device for measuring and controlling the level of a blood constituent, such as glucose, in a mammal, and includes an implantable infrared source and sensor module for directing infrared radiation through vascular tissue and for sensing the infrared radiation after it has passed through the tissue and generating an output signal representative of the sensed infrared radiation. The device includes a processor module responsive to the output signal from the infrared source and sensor module which performs spectral analysis of the output signal and derives from that analysis a control signal representative of the level of the blood constituent. The device further includes an insulin pump for dispensing doses of insulin in response to the control signal for blood glucose regulation.

6122536, Sep 19, 2000

Jun 23, 1998

8/981860

Xiaoguong Sun - King of Prussia PA
Jeffrey I. Joseph - Penn Valley PA
Katherine D. Crothall - Gladwyne PA

Animas Corporation - Malvern PA

A61B 500, A61M 5142

600341

This invention is an implantable sensor and system capable of measuring, controlling, monitoring and reporting blood constituent levels. The implantable sensor for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue having at least one source of radiation from infrared through visible light, arranged to direct the radiation at the tissue where it is affected by interaction with the tissue, and at least one detector. The invention also encompasses a device for measuring and controlling the level of a blood constituent, such as glucose or oxygen, and includes an implantable infrared source module for generating an output signal representative of the sensed infrared radiation. The system includes a processor module responsive to the output signal which performs spectral analysis of the output signal and generates a control signal. The system further includes other devices for dispensing doses of medications or controlling organ function in response to the control signal.

5819723, Oct 13, 1998

Aug 30, 1996

8/702676

Jeffrey I. Joseph - Penn Valley PA

Thomas Jefferson University - Philadelphia PA

A61M 1600

12820714

An integrated system providing a mechanical and chemical barrier against the spread of infected secretions into the distal trachea is disclosed. An endotracheal tube is used for patient airway management and provides a means to conveniently irrigate and drain the subglottic region below the vocal cords and above an inflated cuff. The subglottic region accumulates liquid secretions that may channel past an inflated endotracheal tube cuff, providing the necessary bacterial inoculum leading to bronchitis and nosocomial pneumonia. An irrigation channel delivers liquids such as saline or antibiotic and antifungal medications for mucosal hydration, and bactericidal action against infected subglottic secretions. An outer sleeve surrounding the endotracheal tube forms a suction lumen for removing the secretions. Electronic and mechanical controls provide regulated volume infusion and regulated suction.

5582167, Dec 10, 1996

Mar 2, 1994

8/204481

Jeffrey I. Joseph - Penn Valley PA

Thomas Jefferson University - Philadelphia PA

A61M 1500

12820715

An integrated system providing a mechanical and chemical barrier against the spread of infected secretions into the distal trachea is disclosed. An endotracheal tube used for patient airway management and provides a means to conveniently irrigate and drain the subglottic region below the vocal cords and above an inflated cuff. The subglottic region accumulates liquid secretions that may channel past an inflated endotracheal tube cuff, providing the necessary bacterial inoculum leading to bronchitis and nosocomial pneumonia. An irrigation channel delivers liquids such as saline or antibiotic and antifungal medications for mucosal hydration, and bactericidal action against infected subglottic secretions. An outer sleeve surrounding the endotracheal tube forms a suction lumen for removing the secretions. The tapered and compliant nature of this sleeve at body temperature allows a large suction channel without the need to greatly enlarge the outside diameter of the endotracheal tube at the vocal cord level.