Inventors:
Jeffrey M. Dodd-o - Baltimore MD
David B. Pearse - Ellicott City MD
Assignee:
Johns Hopkins University School of Medicine - Baltimore MD
International Classification:
A61K 3119, A61K 3112, A61K 3111, A61K 31075, A61K 3105
Abstract:
The present invention is directed to a method for the prophylactic and therapeutic treatment of reperfusion injury or injury due to a distal reperfusion. The method involves the administration of an NADPH-oxidase inhibitor to a cell, tissue, organ or animal in an amount sufficient to treat the cell, tissue, organ or animal for reperfusion injury prophylactically or therapeutically. The NADPH-oxidase inhibitor preferably is an o-methoxycatechol, or a pharmaceutically acceptable salt, derivative, dimer or prodrug thereof. Most preferably, the o-methoxycatechol is apocynin.