Inventors:
PALATIN TECHNOLOGIES, INC. - Cranbury NJ, US
Jennifer Lata - New Hope PA, US
Jeffrey D. Edelson - Berwyn PA, US
Assignee:
PALATIN TECHNOLOGIES, INC. - Cranbury NJ
International Classification:
A61K 38/10, C07K 7/08, A61P 11/06, A61P 11/00
Abstract:
Use of constructs which bind to one or more natriuretic peptide receptors and include a plurality of amino acid residues and at least one amino acid surrogate of formula I:where R, R′, Q, Y, W, Z, J, x and n are as defined in the specification, and optionally at least one prosthetic group, for the prophylaxis or treatment of airway diseases, including but not limited to inflammation-related airway diseases, acute asthma or COPD, methods of prophylaxis and treatment of airway diseases and pharmaceutical compositions and formulations for the prophylaxis or treatment of airway diseases.