Inventors:
Cheryl Winkler - Gaithersburg MD, US
George Nelson - Thurmont MD, US
Jeffrey B. Kopp - Bethesda MD, US
Michael W. Smith - Jefferson MD, US
Randall Johnson - Frederick MD, US
International Classification:
C12Q 1/68, C40B 40/06
Abstract:
Methods for determining the genetic predisposition of a human subject to developing renal disease, such as focal segmental glomerulosclerosis (FSGS) or end-stage kidney disease are provided herein. These methods include methods for detecting renal disease, or determining the risk of developing renal disease in a human subject, such as a subject of African ancestry. The methods utilize the detection of one or more haplotype blocks comprising at least two tag single nucleotide polymorphisms (SNPs) in a non-coding region of a MYH9 gene or detecting the presence of at least one tag SNP in a non-coding region of a MYH9 gene. An array for detecting a genetic predisposition to renal disease using probes complementary to the tag SNPs in the non-coding region of the MYH9 gene are also disclosed.