JEFFREY BAKER, M.D.
Medical Practice at Erwin Rd, Durham, NC
License number
North Carolina 38892
Category
Osteopathic Medicine
Type
Emergency Medicine
License number
North Carolina 38892
Category
Medical Practice
Type
Pediatrics
Address
Address
2100 Erwin Rd, Durham, NC 27710
Phone
(919) 620-4467
Personal information
See more information about JEFFREY BAKER at radaris.comName
Address
Phone
4913 Berry Rose Way, Cary, NC 27518
4909 Carlton Crossing Dr, Durham, NC 27713
4800 Alamance Rd APT C, Fayetteville, NC 28304
4413 Fox Rd, Raleigh, NC 27616
Professional information
See more information about JEFFREY BAKER at trustoria.com
Jeffrey Paul Baker, Durham NC
Jeffrey Paul Baker, Durham NC
Specialties:
Pediatrics, Emergency Medicine, General Practice
Work:
Duke Children's Primary Care
6301 Herndon Rd, Durham, NC 27713
6301 Herndon Rd, Durham, NC 27713
Education:
Duke University(1984)
Jeffrey Baker, Durham NC
Jeffrey Baker, Durham NC
Specialties:
Pediatrician
Address:
2100 Erwin Rd, Durham, NC 27705
Matrix Metalloproteinase-7 (Mmp-7) Monoclonal Antibodies And Methods For Their Use In The Detection Of Ovarian Cancer
Matrix Metalloproteinase-7 (Mmp-7) Monoclonal Antibodies And Methods For Their Use In The Detection Of Ovarian Cancer
US Patent:
2010022, Sep 9, 2010
Filed:
Mar 5, 2010
Appl. No.:
12/718603
Inventors:
Jeffrey P. Baker - Durham NC, US
Robert L. Cheek - Mebane NC, US
Eric P. Dixon - Cary NC, US
Timothy J. Fischer - Raleigh NC, US
Steven L. Knapp - Apex NC, US
Stephen G. Simkins - Fuquay-Varina NC, US
Clark M. Whitehead - Apex NC, US
Robert L. Cheek - Mebane NC, US
Eric P. Dixon - Cary NC, US
Timothy J. Fischer - Raleigh NC, US
Steven L. Knapp - Apex NC, US
Stephen G. Simkins - Fuquay-Varina NC, US
Clark M. Whitehead - Apex NC, US
Assignee:
Becton, Dickinson and Company - Franklin Lakes NJ
International Classification:
G01N 33/574, C07K 16/18, C12N 5/12, C07K 14/435, C07K 7/08, C07H 21/04, C12P 21/04, G01N 33/53
US Classification:
435 74, 53038826, 5303879, 435346, 530324, 530326, 536 235, 435 7021, 435331, 435 79
Abstract:
Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MMP-7. Monoclonal antibodies having the binding characteristics of an MMP-7 antibody of the invention and monoclonal antibodies that bind to an MMP-7 epitope of a disclosed antibody are further provided. Hybridoma cell lines that produce an MMP-7 monoclonal antibody of the invention are also disclosed herein. The compositions find use in diagnostic methods as well as in screening methods for identifying patients having an increased likelihood of having ovarian cancer. Kits comprising one or more of the disclosed MMP-7 monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an MMP-7 epitope of a disclosed monoclonal MMP-7 antibody and methods of using these polypeptides in the production of MMP-7 antibodies are also encompassed by the present invention.