Inventors:
Mark I. Greene - Penn Valley PA
William V. Williams - Havertown PA
David B. Weiner - Merion PA
Jeffrey A. Cohen - Solon OH
Thomas Kieber-Emmons - Newtown Square PA
Robert M. Williams - Fort Collins CO
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C07K 700
US Classification:
530333, 530300, 530350, 5303872, 53038827, 5303883, 53038835, 4241851, 4241841, 4241931, 4242151, 435 71, 514 2, 514 12, 514 13, 514 14
Abstract:
A method of constructing biologically active compounds which mimic the biological activity of the biologically active protein block the activity of the biologically active protein is disclosed. A method of identifying specific and discrete portions of pathogen antigens which either serve as epitopes for neutralizing antibodies or which are involved in pathogen binding to host cell receptors is disclosed. A method of constructing biologically active compounds which compete with cellular receptors for binding to either biologically active proteins or pathogen antigens is disclosed.