JEFFERY CARL LESHO
Pilots at Eagles Rdg Ct, Unity, MD

6400974, Jun 4, 2002

Jun 29, 2000

09/605706

Jeffery C. Lesho - Brookeville MD

Sensors for Medicine and Science, Inc. - Germantown MD

A61B 505

600347, 600365, 600345

A quantitative measurement system includes an external unit and an internal unit are provided for obtaining quantitative analyte measurements, such as within the body. In one example of an application of the system, the internal unit would be implanted either subcutaneously or otherwise within the body of a subject. The internal unit contains optoelectronics circuitry, a component of which may be comprised of a fluorescence sensing device. The optoelectronics circuitry obtains quantitative measurement information and modifies a load as a function of the obtained information. The load in turn varies the amount of current through coil, which is coupled to a coil of the external unit. A demodulator detects the current variations induced in the external coil by the internal coil coupled thereto, and applies the detected signal to processing circuitry, such as a pulse counter and computer interface, for processing the signal into computer-readable format for inputting to a computer.

7553280, Jun 30, 2009

Jun 27, 2001

10/332619

Jeffery C. Lesho - Brookeville MD, US

Sensors for Medicine and Science, Inc. - Germantown MD

A61B 5/00, A61B 6/00

600365, 600309, 600310, 600316, 600476, 600477

A quantitative measurement system includes an external unit () and an internal unit () are provided for obtaining quantitative analyte measurements, such as within the body. In one example of an application of the system, the internal unit () would be implanted either subcutaneously or otherwise within the body of a subject. The internal unit () contains optoelectronics circuitry (), a component of which may be comprised of a fluorescence sensing device. The optoelectronics circuitry () obtains quantitative measurement information and modifies a load () as a function of the obtained information. The load () in turn varies the amount of current through coil (), which is coupled to a coil () of the external unit (). A demodulator () detects the current variations induced in the external coil () by the internal coil () coupled thereto, and applies the detected signal to processing circuitry, such as a pulse counter () and computer interface (), for processing the signal into computer-readable format for inputting to a computer ().

2009026, Oct 22, 2009

Jun 29, 2009

12/493478

Jeffery C. LESHO - Brookeville MD, US

Sensors for Medicine and Science,Inc. - Germantown MD

A61B 5/1455

600310

A quantitative measurement system includes an external unit and an internal unit are provided for obtaining quantitative analyte measurements, such as within the body. In one example of an application of the system, the internal unit would be implanted either subcutaneously or otherwise within the body of a subject. The internal unit contains optoelectronics circuitry, a component of which may be comprised of a fluorescence sensing device. The optoelectronics circuitry obtains quantitative measurement information and modifies a load as a function of the obtained information. The load in turn varies the amount of current through coil, which is coupled to a coil of the external unit. A demodulator detects the current variations induced in the external coil by the internal coil coupled thereto, and applies the detected signal to processing circuitry, such as a pulse counter and computer interface, for processing the signal into computer-readable format for inputting to a computer.

5842977, Dec 1, 1998

Jul 23, 1996

8/685375

Jeffery C. Lesho - Brookeville MD
Harry A. C. Eaton - Columbia MD

The Johns Hopkins University - Baltimore MD

A61B 500

600300

An optical interface incorporated into a multi-channel telemetry device used principally to provide data representing physiological conditions in a human subject. Information is transmitted without the need of a bio-compatible electrical connection via an optical link which conveys calibration parameters and commands to control the operation of the telemeter. The optical link is configured to reside completely on an integrated circuit chip. Of the three channels designed into the chip by means of appropriate electronic circuitry, one of the channels measures temperature and the other two channels are dedicated to develop generic information selectively derived from other physiological conditions. Calibration information that is programmed into the telemeter by means of the optical interface is retrieved by time division multiplexing with one of the generic channels.

4844076, Jul 4, 1989

Aug 26, 1988

7/236885

Jeffery C. Lesho - Brookeville MD
Arthur F. Hogrefe - Laurel MD

The Johns Hopkins University - Baltimore MD

A61B 507

128631

A temperature responsive transmitter is disclosed. The transmitter utilizes a unique circuit design that allows encapsulation in an ingestible size capsule. The inventive circuit design uses a one transistor inverting amplifier with a tank circuit forming the link between the transistor's collector and the battery. The tank circuit is tuned to provide a lagging capacitive load which causes the inverting amplifier to oscillate. The tank circuit contains a coil inductor that emits a near field magnetic communications field containing temperature information. The ingestible size temperature pill can be configured in a rechargeable embodiment. In this embodiment the pill uses the inductive coil in the tank circuit as the magnetic pickup to charge a rechargeable nickel cadmium battery.

8502167, Aug 6, 2013

May 19, 2008

12/123087

Jeffery C. Lesho - Brookeville MD, US
Carrie R. Lorenz - Woodbine MD, US

Sensors For Medicine and Science, Inc. - Germantown MD

G01N 21/64

2504591, 2502521

The present invention provides a method for increasing the lifetime of an optical sensor. In one aspect, the method includes the step of configuring the optical sensor so that the duty cycle of sensor's radiant source is less than 100% over a continuous period amount of time when the sensor is periodically obtaining data regarding an analyte. By operating the sensor according to the above inventive method, the indicator molecules of the optical sensor are not excited during the entire continuous period of time during which the sensor is needed to provide data regarding the presence or concentration of a substance. Thus, the method increases the life of the indicator molecules.

2004015, Aug 12, 2004

Aug 22, 2003

10/646286

Carl Nelson - Derwood MD, US
Jeffery Lesho - Brookeville MD, US

G08B001/00

340/531000

Disclosed herein is an audible alarm relay system comprising a microphone for converting environmental sounds to electrical sound signals; processing circuitry for receiving the electrical sound signals, sampling the sound signals, and analyzing the sampled sound signals to determine if the sampled sound signals contain a sound pattern that matches a stored sound pattern; and an output device for notifying a user that the sampled sound signal contains a sound pattern that matches a stored sound pattern.

6330464, Dec 11, 2001

Aug 26, 1999

9/383148

Arthur E. Colvin - Mr. Airy MD
Gregory A. Dale - Gaithersburg MD
Paul Samuel Zerwekh - Monrovia MD
Jeffery C. Lesho - Brookeville MD
Robert W. Lynn - Silver Spring MD

Sensors for Medicine & Science - Germantown MD

A61B 500

600316

An optical-based sensor for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body with a source of radiation embedded therein. Radiation emitted by the source interacts with indicator membrane indicator molecules proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For example, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e. g. , light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body.

7375347, May 20, 2008

Apr 26, 2004

10/831346

Jeffery C. Lesho - Brookeville MD, US
Carrie R. Lorenz - Woodbine MD, US

Sensors for Medicine and Science, Inc. - Germantown MD

G01N 21/64

2504591, 2502521

The present invention provides a method for increasing the lifetime of an optical sensor. In one aspect, the method includes the step of configuring the optical sensor so that the duty cycle of sensor's radiant source is less than 100% over a continuous period amount of time when the sensor is periodically obtaining data regarding an analyte. By operating the sensor according to the above inventive method, the indicator molecules of the optical sensor are not excited during the entire continuous period of time during which the sensor is needed to provide data regarding the presence or concentration of a substance. Thus, the method increases the life of the indicator molecules.