Inventors:
Jeanne Y. Wei - Little Rock AR, US
Gohar Azhar - Little Rock AR, US
Xiaomin Zhang - Little Rock AR, US
International Classification:
C12Q 1/00, C12Q 1/68, A61K 48/00, C07H 21/04
US Classification:
435 4, 435 6, 514 44 R, 536 245
Abstract:
The invention provides a method of identifying candidate agents to test for treating heart failure involving diastolic impairment, the method comprising: testing an agent to determine whether it (a) binds to serum response factor (SRF), (b) reduces SRF binding to a serum response element (SRE), or (c) reduces SRF protein levels in a cell; wherein if the agent does one or more of (a), (b), and (c), it is identified as a candidate agent.