Inventors:
Omer Aras - Baltimore MD, US
Thorsten Fleiter - Owings Mills MD, US
Jean Jeudy - Baltimore MD, US
Marie-Christine Daniel - Catonsville MD, US
International Classification:
A61K 49/00, C07D 207/16, A61K 49/04, A61K 49/06, B32B 5/16, B82Y 15/00
US Classification:
424 91, 548533, 424 944, 424 93, 428402, 977773, 977810, 977927, 977928, 977930
Abstract:
Overexpression of angiotensin-converting enzyme (ACE) has been associated with a number of pathophysiologies, including those associated with cancer and the cardiovascular system. Thus, targeted imaging of ACE is of crucial importance for monitoring tissue ACE activity as well as treatment efficacy. To this end, lisinopril-coated gold nanoparticles were prepared to provide a new type of probe for targeted molecular imaging of ACE by tuned K-edge computed tomography (CT) imaging.