JAYANTA R ROY-CHOWDHURY, MD
Osteopathic Medicine at Blondell Ave, Bronx, NY

2004002, Feb 5, 2004

Mar 4, 2003

10/377628

Jayanta Roy-Chowdhury - New Rochelle NY, US
Yaron Ilan - Bronx NY, US
Elazar Rabbani - New York NY, US
Dean Engelhardt - New York NY, US

Enzo Therapeutics, Inc

A61K048/00, A61K039/395

424/093200, 424/155100

Novel immune modulating processes are provided in which the immunological state of a subject including mature subjects, mammals and humans, are down regulated in a selective manner, and as a subset in a dominant manner. The novel immunological state termed SIDR for selective immune down regulation is usefully applied to the immunological modulation or regulation of gene delivery components, artificially expressed genes, gene delivery systems and expression products of artificially introduced genes by such delivery systems, and infectious agents. SIDR is also useful when combined with other immune modulating treatments such as general immune suppression and anti-apoptosis. SIDR may also be used to selectively down regulate the immune response system of a subject to a wide variety of noncellular immunogenic components and to native antigens. Other processes for producing immune suppression by administering macromolecules or compounds to a subject so as to obtain or effect SIDR are also provided. Kits for carrying out the novel processes are also provided.

2004002, Feb 5, 2004

Mar 4, 2003

10/377603

Jayanta Roy-Chowdhury - New Rochelle NY, US
Yaron Ilan - Bronx NY, US
Elazar Rabbani - New York NY, US
Dean Engelhardt - New York NY, US

Enzo Therapeutics, Inc

A61K039/395, A61K048/00

514/044000, 424/093200, 424/145100

Novel immune modulating processes are provided in which the imunological state of a subject including mature subjects, mammals and humans, are down regulated in a selective manner, and as a subset in a dominant manner. The novel immunological state termed SIDR for selective immune down regulation is usefully applied to the immunological modulation or regulation of gene delivery components, artificially expressed genes, gene delivery systems and expression products of artificially introduced genes by such delivery systems, and infectious agents. SIDR is also useful when combined with other immune modulating treatments such as general immune suppression and anti-apoptosis. SIDR may also be used to selectively down regulate the immune response system of a subject to a wide variety of noncellular immunogenic components and to native antigens. Other processes for producing immune suppression by administering macromolecules or compounds to a subject so as to obtain or effect SIDR are also provided. Kits for carrying out the novel processes are also provided.

6524613, Feb 25, 2003

Jun 30, 1998

09/108006

Clifford J. Steer - St. Paul MN
Betsy T. Kren - Minneapolis MN
Paramita Bandyopadhyay - Minneapolis MN
Jayanta Roy-Chowdhury - New Rochelle NY

Regents of the University of Minnesota - Minneapolis MN
Yeshiva University - Bronx NY

A61K 9127

424450, 514 44, 536 231, 536 241, 536 243

The present invention concerns compositions and methods for the introduction of specific genetic changes in endogenous genes of the cells of an animal. The genetic changes are effected by oligonucleotides or oligonucleotide derivatives and analogs, which are generally less than about 100 nucleotides in length. The invention provides for macromolecular carriers, optionally incorporating ligands for clathrin coated pit receptors. In one embodiment the ligand is a lactose or galactose and the genetic changes are made in hepatocytes. By means of the invention up to 40% of the copies of a target gene have been changed in vitro. Repair of mutant genes having a Crigler-Najjar like phenotype and Hemophilia B phenotype were observed.

2001000, Jul 5, 2001

Jun 16, 1997

08/876635

JENNIFER JUNE BROWN - BRONX NY, US
ELAZAR RABBANI - NEW YORK NY, US
JAMES J. DONEGAN - LONG BEACH NY, US
JAYANTA ROY-CHOWDHURY - NEW ROCHELLE NY, US

A01K067/00, A01K067/033, A01K067/027

800/008000, 800/009000, 800/010000, 800/011000, 800/012000, 800/013000, 800/014000, 800/018000

This invention provides useful solid chimeric organs as well as animal models having such solid chimeric organs and processes for their preparation. Such organs find significant value and use in developing new models for disease, drug and therapeutic investigations and monitoring, and in studying storage functions and processes. The solid chimeric organs are comprised of recipient cells and donor cells, the latter themselves comprising allogeneic or xenogeneic cells which are unmodified or modified to contain one or more nucleic acid segments capable of exhibiting at least one biological property, e.g. DNA synthesis, replication, promoter function, transcription, translation, reverse transcription, and the like, non-native to the donor cell. The solid chimeric organs can be prepared from recipient organs using recipient cells and implanted allogeneic or xenogeneic donor cells from non-homologous organs or tissues. Also provided by this invention are non-tumorigenic immortalized human cell lines modified by having sequences derived from hepatotrophic viruses introduced into the cells. Susceptible cells, cytopathic mammalian viruses, target cells rendered susceptible to cytopathic events, and human cells infected or transfected by noncytopathic viruses are also provided.

2003017, Sep 11, 2003

Mar 12, 2003

10/385440

Jayanta Roy-Chowdhury - New Rochelle NY, US
Yaron Ilan - Jerusalem, IL
Elazar Rabbani - New York NY, US
Dean Engelhardt - New York NY, US

Enzo Therapeutics, Inc.

A61K039/12, A61K039/29, A61K039/02, A61K039/21, A61K038/13, A61K031/739

424/186100, 424/188100, 424/190100, 514/011000, 514/054000, 424/189100

Novel immune modulating processes are provided in which the imunological state of a subject including mature subjects, mammals and humans, are down regulated in a selective manner, and as a subset in a dominant manner. The novel immunological state termed SIDR for selective immune down regulation is usefully applied to the immunological modulation or regulation of gene delivery components, artificially expressed genes, gene delivery systems and expression products of artificially introduced genes by such delivery systems, and infectious agents. SIDR is also useful when combined with other immune modulating treatments such as general immune suppression and anti-apoptosis. SIDR may also be used to selectively down regulate the immune response system of a subject to a wide variety of noncellular immunogenic components and to native antigens. Other processes for producing immune suppression by administering macromolecules or compounds to a subject so as to obtain or effect SIDR are also provided. Kits for carrying out the novel processes are also provided.

8012456, Sep 6, 2011

Dec 12, 2001

10/042711

Jennifer June Brown - Bronx NY, US
Elazar Rabbani - New York NY, US
James J. Donegan - Long Beach NY, US
Jayanta Roy-Chowdhury - New Rochelle NY, US

Enzo Therapeutics, Inc. - Farmingdale NY

A61K 49/00, A01K 67/00, A01K 67/033

424 91, 424 92, 800 8, 800 9

This invention provides novel animal models for a human pathogen that is capable of exhibiting analogous secondary disease manifestation. Other animal models for a human pathogen are provided by this invention which are capable of exhibiting analogous secondary disease manifestations and are also capable of responding to therapeutic or preventive measures to such secondary disease manifestations. Other animal models for human retrovirus infections are provided including lower primates and primate excluding any members of the order Anthropoidea. Compositions, drugs, products and procedures for therapeutic and diagnostic applications derived from the animal models of this invention are also described and provided.