DR. JAY PETERS, MD
Osteopathic Medicine in San Antonio, TX

2010018, Jul 22, 2010

Jan 10, 2008

12/522774

Robert O. Williams - Austin TX, US
Keith P. Johnston - Austin TX, US
Prapasri Sinswat - Austin TX, US
Jason T. McConville - Austin TX, US
Robert Talbert - San Antonio TX, US
Jay I. Peters - San Antonio TX, US
Alan B. Watts - Austin TX, US
True L. Rogers - Midland TX, US

Board of Regents, The University of Texas System - Austin TX

A61K 9/14, A61K 31/436, A61P 37/00, A61P 11/00

424484, 514291, 977788

The present invention includes compositions and methods for making and using a rapid dissolving, high potency, substantially amorphous nanostructured aggregate for pulmonary delivery of tacrolimus and a stabilizer matrix comprising, optionally, a polymeric or non-polymeric surfactant, a polymeric or non-polymeric saccharide or both, wherein the aggregate comprises a surface area greater than 5 m/g as measured by BET analysis and exhibiting supersaturation for at least 0.5 hours when 11-15-times the aqueous crystalline solubility of tacrolimus is added to simulated lung fluid.

2011022, Sep 15, 2011

May 6, 2009

12/991403

Robert O. Williams III - Austin TX, US
Rupert O. Zimmerer - Lawrence KS, US
Justin A. Tolman - Papillion NE, US
Nathan P. Wiederhold - San Antonio TX, US
Jay I. Peters - San Antonio TX, US

Board of Regents, The University of Texas System - Austin TX
CyDex Pharmaceuticals, Inc. - Lenexa KS

A61K 31/506, A61P 31/10

514256

A method of treating fungal infection by pulmonary administration of a solution of voriconazole and cyclodextrin is provided The fungal infection can be a pulmonary infection. The solution can be an inhalable aqueous formulation that can be administered via the mouth or nose. The cyclodextrin can be a water soluble cyclodextrin derivative such as sulfoalkyl ether cyclodextrin. The formulation can be administered via a spray device or nebulizer.

2007028, Dec 13, 2007

Aug 26, 2005

11/660012

James Hitt - Midland MI, US
True Rogers - Midland MI, US
Brian Scherzer - Midland MI, US
Ian Gillespie - Linden MI, US
Paula Garcia - Midland MI, US
Nicholas Beck - Midland MI, US
Christopher Tucker - Midland MI, US
Timothy Young - Bay City MI, US
David Hayes - Midland MI, US
Robert Williams III - Austin TX, US
Keith Johnston - Austin TX, US
Jason McConville - Austin TX, US
Jay Peters - San Antonio TX, US
Robert Talbert - San Antonio TX, US
David Burgess - San Antonio TX, US

THE DOW CHEMICAL COMPANY - Midland MI
BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM - Austin TX

A61K 31/7048, A61K 31/16, A61K 31/4164, A61K 31/4196, A61P 31/00, A61K 31/496, A61K 31/5375

514031000, 514231200, 514254070, 514256000, 514274000, 514383000, 514396000, 514399000, 514599000, 514789000

Inhalable compositions are described. The inhalable compositions comprise one or more respirable aggregates, the respirable aggregates comprising one or more poorly water soluble active agents, wherein at least one of the active agents reaches a maximum lung concentration (C) of at least about 0.25 μg/gram of lung tissue and remains at such concentration for a period of at least one hour after being delivered to the lung. Methods for making such compositions and methods for using such compositions are also disclosed.