Inventors:
James Hitt - Midland MI, US
True Rogers - Midland MI, US
Brian Scherzer - Midland MI, US
Ian Gillespie - Linden MI, US
Paula Garcia - Midland MI, US
Nicholas Beck - Midland MI, US
Christopher Tucker - Midland MI, US
Timothy Young - Bay City MI, US
David Hayes - Midland MI, US
Robert Williams III - Austin TX, US
Keith Johnston - Austin TX, US
Jason McConville - Austin TX, US
Jay Peters - San Antonio TX, US
Robert Talbert - San Antonio TX, US
David Burgess - San Antonio TX, US
Assignee:
THE DOW CHEMICAL COMPANY - Midland MI
BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM - Austin TX
International Classification:
A61K 31/7048, A61K 31/16, A61K 31/4164, A61K 31/4196, A61P 31/00, A61K 31/496, A61K 31/5375
US Classification:
514031000, 514231200, 514254070, 514256000, 514274000, 514383000, 514396000, 514399000, 514599000, 514789000
Abstract:
Inhalable compositions are described. The inhalable compositions comprise one or more respirable aggregates, the respirable aggregates comprising one or more poorly water soluble active agents, wherein at least one of the active agents reaches a maximum lung concentration (C) of at least about 0.25 μg/gram of lung tissue and remains at such concentration for a period of at least one hour after being delivered to the lung. Methods for making such compositions and methods for using such compositions are also disclosed.