DR. JAY NORMAN COHN, M.D.
Osteopathic Medicine in Minneapolis, MN

4868179, Sep 19, 1989

Apr 22, 1987

7/041210

Jay N. Cohn - Minneapolis MN

A61K 3134, A61K 3150

514248

A method of reducing mortality associated with chronic congestive heart failure in a patient with impaired cardiac function and concomitant reduced exercise tolerance, comprising the oral administration to said patient in need of the same of a combination of (a) between about 75 and about 300 milligrams of hydralazine, per day and (b) between about 40 and about 160 milligrams of isosorbide dinitrate, per day.

8636660, Jan 28, 2014

Oct 9, 2012

13/648168

Jay N. Cohn - Minneapolis MN, US

Regents of the University of Minnesota - St. Paul MN

A61B 5/00

600301, 600509

A system and method for dynamic multi-stage test administration for detection of cardiovascular disease may include performing a first set of tests in a first stage of testing on a patient. Physiological results for each of the tests in the first stage may then be received. Then, based on the physiological results, dynamically determining a set of tests to perform on the subject in a second stage of testing. Additionally, the dynamically determined set of tests in the second stage of testing may be performed on the subject.

6689069, Feb 10, 2004

May 28, 2002

10/157551

Christopher W. Bratteli - Fridley MN
Jay N. Cohn - Minneapolis MN
Stanley M. Finkelstein - St. Louis Park MN
Dennis J. Morgan - Crystal MN

Hypertension Diagnostics, Inc. - Eagan MN

A61B 502

600485, 600481, 600500, 128898

Methods and apparatus for processing an arterial blood pressure waveform to extract clinically useful information on the state of the cardiovascular system are disclosed herein. In order to obtain the parameters of the modified Windkessel model, the diastolic portion of a subjects blood pressure waveform is scanned over a plurality of ranges and the range that produces the best fit of data and lowest error estimates are selected. In addition, multiple empirically determined starting values of the ‘A’ parameters are used to find the best fit of the model data to the actual arterial blood pressure waveform data.

6623434, Sep 23, 2003

Sep 17, 2001

09/954673

Charles F. Chesney - Sunfish Lake MN
Stanley M. Finkelstein - St. Louis Park MN
Jay N. Cohn - Minneapolis MN

Hypertension Diagnostics, Inc. - Eagan MN

A61B 5021

600485, 600481

A vascular impedance measurement instrument includes a transducer to obtain a digitized arterial blood pressure waveform. The digitized data is used to determine cardiac output, and to subsequently obtain measurements of impedance parameters using the modified Windkessel model of the arterial system. The instrument is used as an aid in diagnosing, treating and monitoring patients with cardiovascular disease.

2008022, Sep 18, 2008

Mar 21, 2008

12/053346

Jay N. COHN - Minneapolis MN, US
Peter CARSON - Chevy Chase MD, US

NITROMED, INC. - Lexington MA

A61K 33/00, A61K 31/502, A61K 31/55, A61K 31/351, A61K 31/403, A61K 31/4422, A61K 31/4178, A61K 31/506, A61K 31/40, A61P 9/10

424722, 514248, 51421007, 514460, 514411, 514356, 514381, 514269, 514423

The present invention provides methods of treating and preventing mortality associated with heart failure in an African American patient with hypertension and improving oxygen consumption, quality of life and exercise tolerance by administering a therapeutically effective amount of at least one hydralazine compound and at least one of isosorbide dinitrate and isosorbide mononitrate, and, optionally, one or more compounds, such as, for example, a digitalis, a diuretic compound, or a compound used to treat cardiovascular diseases. In the present invention, the hydralazine compound is preferably hydralazine or a pharmaceutically acceptable salt thereof. Preferred methods of the invention comprise administering hydralazine or a pharmaceutically acceptable salt thereof and isosorbide dinitrate.

5876347, Mar 2, 1999

Sep 23, 1997

8/935568

Charles F. Chesney - Sunfish Lake MN
Stanley M. Finkelstein - St. Louis Park MN
Jay N. Cohn - Minneapolis MN

Regents of the University of Minnesota - Minneapolis MN

A61B 5021

600485

A vascular impedance measurement instrument includes a transducer to obtain a digitized arterial blood pressure waveform. The digitized data is used to determine cardiac output, and to subsequently obtain measurements of impedance parameters using the modified Windkessel model of the arterial system. The instrument is used as an aid in diagnosing, treating and monitoring patients with cardiovascular disease.

6290651, Sep 18, 2001

Apr 10, 2000

9/545946

Charles F. Chesney - Sunfish Lake MN
Stanley M. Finkelstein - St. Louis Park MN
Jay N. Cohn - Minneapolis MN

Hypertension Diagnostics, Inc. - Eagan MN

A61B 5021

600485

A vascular impedance measurement instrument includes a transducer to obtain a digitized arterial blood pressure waveform. The digitized data is used to determine cardiac output, and to subsequently obtain measurements of impedance parameters using the modified Windkessel model of the arterial system. The instrument is used as an aid in diagnosing, treating and monitoring patients with cardiovascular disease.

5316004, May 31, 1994

Mar 26, 1993

8/038357

Charles F. Chesney - Sunfish Lake MN
Stanley M. Finkelstein - St. Louis Park MN
Jay N. Cohn - Minneapolis MN

Regents of the University of Minnesota - Minneapolis MN

A61B 5021

128672

A vascular impedance measurement instrument includes a transducer to obtain a digitized arterial blood pressure waveform. The digitized data is used to determine cardiac output, and to subsequently obtain measurements of impedance parameters using the modified Windkessel model of the arterial system. The instrument is used as an aid in diagnosing, treating and monitoring patients with cardiovascular disease.

6017313, Jan 25, 2000

Mar 20, 1998

9/045420

Christopher W. Bratteli - Fridley MN
Jay N. Cohn - Minneapolis MN
Stanley M. Finkelstein - St. Louis Park MN
Dennis J. Morgan - Crystal MN

Hypertension Diagnostics, Inc. - Eagan MN

A61N 500

600485

Methods and apparatus for processing an arterial blood pressure waveform to extract clinically useful information on the state of the cardiovascular system are disclosed herein. In order to obtain the parameters of the modified Windkessel model, the diastolic portion of a subject's blood pressure waveform is scanned over a plurality of ranges and the range that produces the best fit of data and lowest error estimates are selected. In addition, multiple empirically determined starting values of the `A` parameters are used to find the best fit of the model data to the actual arterial blood pressure waveform data.