DR. JAY NADEL, M.D.
Osteopathic Medicine at Parnassus Ave, San Francisco, CA

6551989, Apr 22, 2003

May 24, 2001

09/865239

Jay A. Nadel - San Francisco CA
Kiyoshi Takeyama - San Francisco CA

The Regents of the University of California - Oakland CA

A01N 6100

514 1, 424 113, 424452, 514 4, 514 2

Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic molecule, an antibody, or portion of an antibody that binds to and blocks the EGF receptor. The EGF-R antagonist is preferably administered by injection in an amount sufficient to inhibit formation of goblet cells in pulmonary airways. The degranulation of goblet cells that results in airway mucus production is thereby inhibited. Assays for screening candidate agents that inhibit goblet cell proliferation are also provided.

7358222, Apr 15, 2008

Feb 7, 2003

10/359932

Jay A. Nadel - San Francisco CA, US
Kiyoshi Takeyama - Tokyo, JP

The Regents of the University of California - Oakland CA

A01N 61/00, A01N 37/16

514 1, 514 2, 514 4, 424 113, 424452

Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic molecule, an antibody, or portion of an antibody that binds to and blocks the EGF receptor. The EGF-R antagonist is preferably administered by injection in an amount sufficient to inhibit formation of goblet cells in pulmonary airways. The degranulation of goblet cells that results in airway mucus production is thereby inhibited. Assays for screening candidate agents that inhibit goblet cell proliferation are also provided.

7700547, Apr 20, 2010

Jan 11, 2008

12/013013

Jay A. Nadel - San Francisco CA, US
Kiyoshi Takeyama - San Francisco CA, US

The Regents of the University of California - Oakland CA

A01N 37/15, A01N 61/00, C07K 16/00

514 2, 514 1, 5303871, 5303881, 53038815, 53038822

Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic molecule, an antibody, or portion of an antibody that binds to and blocks the EGF receptor. The EGF-R antagonist is preferably administered by injection in an amount sufficient to inhibit formation of goblet cells in pulmonary airways. The degranulation of goblet cells that results in airway mucus production is thereby inhibited. Assays for screening candidate agents that inhibit goblet cell proliferation are also provided.

7354894, Apr 8, 2008

Mar 31, 2004

10/816159

Jay A. Nadel - San Francisco CA, US
Kiyoshi Takeyama - Tokyo, JP

The Regents of the University of California - Oakland CA

A01N 61/00, A01N 43/04, C12N 5/00, A61K 49/00, G01N 33/53

514 1, 435 6, 435 72, 435377, 424 91, 424 92, 514 44, 536 231

Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic molecule, an antibody, or portion of an antibody that binds to and blocks the EGF receptor. The EGF-R antagonist is preferably administered by injection in an amount sufficient to inhibit formation of goblet cells in pulmonary airways. The degranulation of goblet cells that results in airway mucus production is thereby inhibited. Assays for screening candidate agents that inhibit goblet cell proliferation are also provided.

8048844, Nov 1, 2011

Feb 7, 2003

10/359982

Jay A. Nadel - San Francisco CA, US
Kiyoshi Takeyama - Tokyo, JP

The Regents of the University of California - Oakland CA

A01N 61/00, A61K 51/00

514 1, 514 2, 514 4, 424 113, 424 9

Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic molecule, an antibody, or portion of an antibody that binds to and blocks the EGF receptor. The EGF-R antagonist is preferably administered by injection in an amount sufficient to inhibit formation of goblet cells in pulmonary airways. The degranulation of goblet cells that results in airway mucus production is thereby inhibited. Assays for screening candidate agents that inhibit goblet cell proliferation are also provided.

6846799, Jan 25, 2005

Jul 14, 2000

09/616223

Jay A. Nadel - San Francisco CA, US
Kiyoshi Takeyama - San Francisco CA, US

The Regents of the University of California - Oakland CA

A01N 6100, A01N 4304, G01N 3353, C12N 500, A61K 4900

514 1, 435 6, 435 72, 435377, 536 231, 424 91, 514 44

Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic molecule, an antibody, or portion of an antibody that binds to and blocks the EGF receptor. The EGF-R antagonist is preferably administered by injection in an amount sufficient to inhibit formation of goblet cells in pulmonary airways. The degranulation of goblet cells that results in airway mucus production is thereby inhibited. Assays for screening candidate agents that inhibit goblet cell proliferation are also provided.

8071074, Dec 6, 2011

Feb 27, 2008

12/038718

Jay A. Nadel - San Francisco CA, US
Kiyoshi Takeyama - Tokyo, JP

The Regents of the University of California - Oakland CA

A61K 9/14, A01N 43/54

424 46, 424 45, 514266

Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic molecule, an antibody, or portion of an antibody that binds to and blocks the EGF receptor. The EGF-R antagonist is preferably administered by injection in an amount sufficient to inhibit formation of goblet cells in pulmonary airways. The degranulation of goblet cells that results in airway mucus production is thereby inhibited. Assays for screening candidate agents that inhibit goblet cell proliferation are also provided.