JAY MILTON SHORT
Pilots at Via Esperia, Del Mar, CA
License number
California A1736183
Issued Date
Jul 2016
Expiration Date
Jul 2018
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
12985 Via Esperia, Del Mar, CA 92014
Professional information
Temperature Sensitive Mutants Of Matrix Metalloproteases And Uses Thereof
US Patent:
2010028, Nov 11, 2010
Filed:
Mar 5, 2010
Appl. No.:
12/660894
Inventors:
Louis Bookbinder - San Diego CA, US
Gregory I. Frost - Del Mar CA, US
Gilbert Keller - Belmont CA, US
Gerhard Johann Frey - San Diego CA, US
Hwai Wen Chang - San Marcos CA, US
Jay Milton Short - Del Mar CA, US
Gregory I. Frost - Del Mar CA, US
Gilbert Keller - Belmont CA, US
Gerhard Johann Frey - San Diego CA, US
Hwai Wen Chang - San Marcos CA, US
Jay Milton Short - Del Mar CA, US
International Classification:
A61K 38/48, A61K 38/47, A61P 17/02, A61P 19/00, A61P 17/00, C12N 9/50, C12N 9/96, C07H 21/04, C12N 15/63, C12N 5/10
US Classification:
424 9462, 424 9467, 435219, 435188, 536 232, 4353201, 435325
Abstract:
Provided are modified matrix metalloprotease (MMP) enzymes that exhibit temperature-dependent activity and uses thereof. The MMPs can be used, for example, to treat ECM-mediated diseases or disorders characterized by increased deposition or accumulation of one or more ECM components.
Amylases, Nucleic Acids Encoding Them And Methods For Making And Using Them
US Patent:
2013023, Sep 5, 2013
Filed:
Nov 6, 2012
Appl. No.:
13/669776
Inventors:
Toby Richardson - San Diego CA, US
Gerhard Frey - San Diego CA, US
Carl A. Miller - Raleigh NC, US
Martin Kazaoka - San Diego CA, US
Eric J. Mathur - Carlsbad CA, US
Jay M. Short - Del Mar CA, US
Gerhard Frey - San Diego CA, US
Carl A. Miller - Raleigh NC, US
Martin Kazaoka - San Diego CA, US
Eric J. Mathur - Carlsbad CA, US
Jay M. Short - Del Mar CA, US
Assignee:
VERENIUM CORPORATION - San Diego CA
International Classification:
C12N 9/24
US Classification:
536 232
Abstract:
In one aspect, the invention is directed to polypeptides having an amylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. In one aspect, the polypeptides of the invention can be used as amylases, for example, alpha amylases, to catalyze the hydrolysis of starch into sugars.
Enzymes Having Dehalogenase Activity And Methods Of Use Thereof
US Patent:
7671189, Mar 2, 2010
Filed:
May 5, 2006
Appl. No.:
11/418828
Inventors:
Jay M. Short - Del Mar CA, US
Toby Richardson - San Diego CA, US
Dan E. Robertson - San Diego CA, US
Kevin A. Gray - San Diego CA, US
Toby Richardson - San Diego CA, US
Dan E. Robertson - San Diego CA, US
Kevin A. Gray - San Diego CA, US
Assignee:
Verenium Corporation - San Diego CA
International Classification:
C07H 21/04, C12P 21/06, C12P 21/04, C12P 19/34, C12P 7/56, C12N 9/00, C12N 1/00, C12N 15/00
US Classification:
536 232, 435 691, 435 701, 435 711, 435 912, 435139, 435183, 435243, 4353201
Abstract:
The invention relates to haloalkane dehalogenases and to polynucleotides encoding the haloalkane dehalogenases. In addition methods of designing new dehalogenases and method of use thereof are also provided. The dehalogenases have increased activity and stability at increased pH and temperature.
Gene Site Saturation Mutagenesis
US Patent:
2011016, Jul 7, 2011
Filed:
Jun 17, 2010
Appl. No.:
12/817616
Inventors:
Jay M. SHORT - Del Mar CA, US
Assignee:
Verenium Corporation - San Diego CA
International Classification:
C12P 19/34
US Classification:
435 912
Abstract:
A method for producing progeny polynucleotides and polypeptides by Gene Site Saturation Mutagenesis (GSSM). The method provides a set of degenerate primers corresponding to codons of a template polynucleotide, and performs polymerase elongation to produce progeny polynucleotides, which contain sequences corresponding to the degenerate primers. The progeny polynucleotides can be expressed and screened for directed evolution.
Comprehensive Monoclonal Antibody Generation
US Patent:
2013028, Oct 24, 2013
Filed:
Dec 28, 2011
Appl. No.:
13/977193
Inventors:
Jay M. Short - Del Mar CA, US
Assignee:
BioAtla, LLC - San Diego CA
International Classification:
G01N 33/68
US Classification:
506 1, 506 9
Abstract:
The present invention relates to methods for efficiently generating recombinant monoclonal antibodies derived from B cells of a non-human host which has been immunochallenged with one or more target antigens. The methods comprise the steps of identifying and isolating B cell that bind to the antigen by FACS, and recombining and enriching for thousands of cells to create a B cell library. Related products and methods, such as methods of producing expression libraries, are also disclosed.
Nitrilases, Nucleic Acids Encoding Them And Methods For Making And Using Them
US Patent:
8318471, Nov 27, 2012
Filed:
Sep 20, 2011
Appl. No.:
13/236862
Inventors:
Grace Desantis - San Diego CA, US
Jay M. Short - Del Mar CA, US
Mark J. Burk - Del Mar CA, US
Kelvin Wong - San Diego CA, US
Robert Farwell - San Diego CA, US
Kelly Chatman - Solana Beach CA, US
Jay M. Short - Del Mar CA, US
Mark J. Burk - Del Mar CA, US
Kelvin Wong - San Diego CA, US
Robert Farwell - San Diego CA, US
Kelly Chatman - Solana Beach CA, US
Assignee:
Verenium Corporation - San Diego CA
International Classification:
C12N 9/78, C12N 15/00, C12N 1/20, C12P 21/04, C12P 21/06, C12Q 1/00, C12Q 1/68, C07H 21/04
US Classification:
435227, 435 4, 435 61, 4352523, 4353201, 435440, 435 691, 435 711, 536 232
Abstract:
The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
Recombinant Bacterial Phytases And Uses Thereof
US Patent:
7452706, Nov 18, 2008
Filed:
Dec 21, 2001
Appl. No.:
10/034985
Inventors:
Jay M. Short - Del Mar CA, US
Keith A. Kretz - San Marcos CA, US
Dan E. Robertson - Belmont MA, US
Keith A. Kretz - San Marcos CA, US
Dan E. Robertson - Belmont MA, US
Assignee:
Verenium Corporation - San Diego CA
International Classification:
C12N 9/16, C12Q 1/44, A23J 1/00, A61K 38/46, C07K 14/00, C12P 21/02, C12N 15/00, C12N 1/21, C12N 1/15, C12N 5/10, C12N 1/19, C07H 21/00
US Classification:
435196, 435 19, 435 691, 4353201, 4352523, 43525411, 43525233, 4352542, 435348, 435325, 424 946, 426656, 530350, 536 232
Abstract:
A purified recombinant phytase enzyme derived from B. The enzyme has a molecular weight of about 47. 1 kilodaltons and has phytase activity. The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of phytate where desired. In particular, the phytase of the present invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients.
Polypeptides Having Amylase Activity And Methods Of Making And Using Them
US Patent:
7781201, Aug 24, 2010
Filed:
Jan 9, 2007
Appl. No.:
11/621534
Inventors:
Walter Callen - San Diego CA, US
Toby Richardson - San Diego CA, US
Gerhard Frey - San Diego CA, US
Jay M. Short - Del Mar CA, US
Eric J. Mathur - Carlsbad CA, US
Kevin A. Gray - San Diego CA, US
Janne S. Kerovuo - San Diego CA, US
Malgorzata Slupska - San Diego CA, US
Toby Richardson - San Diego CA, US
Gerhard Frey - San Diego CA, US
Jay M. Short - Del Mar CA, US
Eric J. Mathur - Carlsbad CA, US
Kevin A. Gray - San Diego CA, US
Janne S. Kerovuo - San Diego CA, US
Malgorzata Slupska - San Diego CA, US
Assignee:
Syngenta Participations AG - Basel
International Classification:
C12N 9/26, C12N 9/28
US Classification:
435201, 435202, 536 232
Abstract:
This invention relates generally to polypeptides and peptides having an amylase activity, e. g. , enzymes, polynucleotides encoding the enzymes, the use of such polypeptides and peptides. In one aspect, the polypeptides having amylase activity have increased activity and stability at acidic, neutral and alkaline pH and increased temperature. In one aspect, the invention provides methods for producing an alcohol, for producing a high-maltose or a high-glucose syrup or a mixed syrup, for liquifying a starch-comprising composition, comprising use of polypeptides having amylase activity of the invention.
Humanized Anti-Il-6 Antibodies
US Patent:
8173398, May 8, 2012
Filed:
Sep 23, 2011
Appl. No.:
13/243915
Inventors:
Gerhard Frey - San Diego CA, US
Hwai Wen Chang - San Marcos CA, US
Jay Short - Del Mar CA, US
Hwai Wen Chang - San Marcos CA, US
Jay Short - Del Mar CA, US
Assignee:
Femta Pharmaceuticals, Inc. - San Diego CA
International Classification:
C12P 21/04, C12P 21/06, C12N 5/00, C07K 16/00, A61K 35/14
US Classification:
435 701, 435 691, 435325, 53038815, 5303881, 530386
Abstract:
The present invention relates to novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
Hydrolase Enzymes And Their Use In Kinetic Resolution
US Patent:
2008022, Sep 18, 2008
Filed:
Jan 22, 2008
Appl. No.:
12/017631
Inventors:
Jay Short - Del Mar CA, US
Eric J. Mathur - Carlsbab CA, US
Markus Baumann - Stuttgart, DE
Uwe T. Bornscheuer - Greifswald, DE
Eric J. Mathur - Carlsbab CA, US
Markus Baumann - Stuttgart, DE
Uwe T. Bornscheuer - Greifswald, DE
Assignee:
Verenium Corporation ( formerly Diversa Corporation ) - San Diego CA
International Classification:
C12Q 1/34, C12N 9/14, C12P 21/04, C40B 30/00
US Classification:
435 18, 435195, 435 691, 506 7
Abstract:
The invention relates to hydrolases and to polypeptides having hydrolase activity. In addition, the invention relates to the use of these hydrolase enzymes in kinetic resolution.