JAY M MCDONALD, MD
Medical Practice at 19 St, Birmingham, AL
License number
Alabama 16277
Category
Medical Practice
Type
Anatomic Pathology
Address
Address
619 19Th St SOUTH, Birmingham, AL 35255
Phone
(205) 934-6600
(205) 731-9701
(205) 731-9701
Personal information
See more information about JAY M MCDONALD at radaris.comName
Address
Phone
1311 Kim Ln SE, Cullman, AL 35055
2934 Jamestown Dr, Montgomery, AL 36111
Professional information
Jay M McDonald, Birmingham AL
Specialties:
Pathologist
Address:
619 19Th St S, Birmingham, AL 35249
Education:
Wayne State University, School of Medicine - Doctor of Medicine
Detroit Receiving Hospital-University Health Center - Residency - Pathology
Detroit Receiving Hospital-University Health Center - Residency - Pathology
Board certifications:
American Board of Pathology Certification in Clinical Pathology (Pathology)
Jay Mckay McDonald, Birmingham AL
Specialties:
Pathology, Anatomic Pathology & Clinical Pathology, Anatomic Pathology
Work:
University of Alabama at Birmingham
619 19Th St S, Birmingham, AL 35249 Birmingham Va Medical Center
700 19Th St S, Birmingham, AL 35233
619 19Th St S, Birmingham, AL 35249 Birmingham Va Medical Center
700 19Th St S, Birmingham, AL 35233
Education:
Wayne State University (1969)
Dr. Jay M Mcdonald, Birmingham AL - MD (Doctor of Medicine)
Specialties:
Anatomic & Clinical Pathology
Address:
UAB Department Of Pathology
619 19Th St S, Birmingham 35249
(205) 934-4303 (Phone)
619 19Th St S SUITE 210, Birmingham 35249
(205) 934-4303 (Phone)
619 19Th St S, Birmingham 35249
(205) 934-4303 (Phone)
619 19Th St S SUITE 210, Birmingham 35249
(205) 934-4303 (Phone)
Certifications:
Anatomic & Clinical Pathology, 1974
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
UAB Department Of Pathology
619 19Th St S, Birmingham 35249
619 19Th St S SUITE 210, Birmingham 35249
University of Alabama Hospital
1802 6Th Ave South, Birmingham 35233
619 19Th St S, Birmingham 35249
619 19Th St S SUITE 210, Birmingham 35249
University of Alabama Hospital
1802 6Th Ave South, Birmingham 35233
Education:
Medical School
Wayne State University School Of Medicine
Graduated: 1969
Oregon
Graduated: 1970
Wayne State University Affil Hospital
Graduated: 1974
Washington University
Graduated: 1976
Wayne State University School Of Medicine
Graduated: 1969
Oregon
Graduated: 1970
Wayne State University Affil Hospital
Graduated: 1974
Washington University
Graduated: 1976
Osteoclast Secreted Chemokine And Uses Thereof
US Patent:
6566333, May 20, 2003
Filed:
Jun 19, 2001
Appl. No.:
09/884570
Inventors:
John P. Williams - Lexington KY
Jay M. McDonald - Birmingham AL
Margaret A. McKenna - Birmingham AL
Jay M. McDonald - Birmingham AL
Margaret A. McKenna - Birmingham AL
Assignee:
UAB Research Foundation - Birmingham AL
International Classification:
A61K 3800
US Classification:
514 12, 514 2, 424 851
Abstract:
The present invention demonstrates the biological function of a newly identified osteoclast-secreted protein. This protein, mim-1, has sequence homology with but is distinct from a previously identified neutrophil chemokine protein. Mim-1 may be a key signaling protein secreted by osteoclasts that regulates recruitment and/or differentiation of osteoblast and osteoclast precursor cells. This protein may also serve to maintain osteoclasts in a relatively inactive state prior to secretion. This mechanism is essential for regulating the mass and structural integrity of bone. This protein or an analog and/or antagonists of this protein will have potential therapeutic potential in the treatment of a variety of pathological bone diseases including osteoporosis and metastatic bone diseases.
Osteoclast Secreted Chemokine And Uses Thereof
US Patent:
6800610, Oct 5, 2004
Filed:
May 29, 2002
Appl. No.:
10/157457
Inventors:
John P. Williams - Lexington KY
Jay M. McDonald - Birmingham AL
Margaret A. McKenna - Birmingham AL
Jay M. McDonald - Birmingham AL
Margaret A. McKenna - Birmingham AL
Assignee:
The UAB Research Foundation - Birmingham AL
International Classification:
A61K 3800
US Classification:
514 12, 514 2, 424 851
Abstract:
The present invention demonstrates the biological function of a newly identified osteoclast-secreted protein. This protein, mim-1, has sequence homology with but is distinct from a previously identified neutrophil chemokine protein. Mim-1 may be a key signaling protein secreted by osteoclasts that regulates recruitment and/or differentiation of osteoblast and osteoclast precursor cells. This protein may also serve to maintain osteoclasts in a relatively inactive state prior to secretion. This mechanism is essential for regulating the mass and structural integrity of bone. This protein or an analog and/or antagonists of this protein will have potential therapeutic potential in the treatment of a variety of pathological bone diseases including osteoporosis and metastatic bone diseases.
Osteoclast Secreted Chemokine And Uses Thereof
US Patent:
7048919, May 23, 2006
Filed:
Oct 4, 2004
Appl. No.:
10/957800
Inventors:
John P. Williams - Lexington KY, US
Jay M. McDonald - Birmingham AL, US
Margaret A. McKenna - Birmingham AL, US
Jay M. McDonald - Birmingham AL, US
Margaret A. McKenna - Birmingham AL, US
Assignee:
The UAB Research Foundation - Birmingham AL
International Classification:
A61K 38/19, A61K 38/00
US Classification:
424 851, 514 2, 514 12
Abstract:
The present invention demonstrates the biological function of a newly identified osteoclast-secreted protein. This protein, mim-1, has sequence homology with but is distinct from a previously identified neutrophil chemokine protein. Mim-1 may be a key signaling protein secreted by osteoclasts that regulates recruitment and/or differentiation of osteoblast and osteoclast precursor cells. This protein may also serve to maintain osteoclasts in a relatively inactive state prior to secretion. This mechanism is essential for regulating the mass and structural integrity of bone. This protein or an analog and/or antagonists of this protein will have potential therapeutic potential in the treatment of a variety of pathological bone diseases including osteoporosis and metastatic bone diseases.
Compositions And Methods For Increasing Osteoblast Cell Differentiation And Bone Generation
US Patent:
2008024, Oct 2, 2008
Filed:
May 3, 2006
Appl. No.:
11/913643
Inventors:
Majd Zayzafoon - Birmingham AL, US
Jay M. McDonald - Birmingham AL, US
Hyeonju Yeo - Birmingham AL, US
Jay M. McDonald - Birmingham AL, US
Hyeonju Yeo - Birmingham AL, US
International Classification:
A61K 38/13, C12Q 1/02, A61K 31/436, A61P 19/00, C12N 5/06
US Classification:
514 11, 435 29, 435377, 435325, 514291
Abstract:
The present invention relates to the discovery of a novel pathway for the induction of osteoblast cellular differentiation and bone generation. Specifically, the present invention envisions a novel screening tool for the determination of compounds capable of promoting osteoblast cellular differentiation that could be used in the treatment of various bone-loss or bone density decreasing disorders. The method of screening of the present invention enables one to determine whether a compound affects certain pathways that promote via direct induction, or the downregulation of inhibiting activity, the differentiation of progenitor cells into osteoblasts. This promotion of osteoblasts could provide for treatments for bone-loss or bone density disorders. The invention further encompasses methods of increasing bone density using the compounds, the compounds, and pharmaceutical compositions comprising the compounds.