Inventors:
Jolanta Grembecka - Charlottesville VA, US
Tomasz Cierpicki - Charlottesville VA, US
Jay Hess - Ann Arbor MI, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI
UNIVERSITY OF VIRGINIA PATENT FOUNDATION - Charlottesville VA
International Classification:
A61K 31/519, C07D 495/04, C07D 491/048, A61K 31/5377, A61K 31/551, C07D 401/04, C07D 405/10, C07D 243/38, A61P 35/04, C12N 5/02
US Classification:
514218, 544250, 51425216, 544278, 544117, 5142342, 540575, 51425211, 540557, 435375
Abstract:
The invention relates generally to effective treatment leukemia. In particular, the present invention provides compositions and methods to inhibit the interaction of menin with MLL and MLL-fusion oncoproteins, and well as systems and methods to screen for such compositions.