DR. JAY A. LEVY, MD
Osteopathic Medicine at Parnassus Ave, San Francisco, CA

5707814, Jan 13, 1998

Mar 5, 1996

8/610942

Jay A. Levy - San Francisco CA
Carl E. Mackewicz - San Francisco CA

The Regents of the University of California - Oakland CA

G01N 3353, G01N 33569, G01N 33542, C07K 100

435 71

A protein secreted by peripheral blood mononuclear cells and specifically from CD8. sup. + lymphocytes is purified and characterized here and designated CD8. sup. + cell antiviral factor (CAF). The CAF is lipid free and has been found to inhibit the replication of retroviruses and in particular to inhibit the replication of HIV-1, HIV-2, and SIV. CAF can be used to inhibit viral RNA transcription which inhibits vital replication. Accordingly, CAF can be used to treat patients infected with retroviruses. The CAF can also generate antibodies which can be used to create assay devices for detecting CAF in a body fluid and on the surface of CD8. sup. + cells to determine the condition of an HIV infected individual.

5858374, Jan 12, 1999

Jun 7, 1995

8/484944

Jay A. Levy - San Francisco CA

University of California - Alameda CA

A61K 3921, A61K 3912, C12Q 170, G01N 3353

4242081

A newly discovered family of AIDS-associated viruses, designated ARV, is described. The viruses were isolated from AIDS patients from San Francisco and (a) are type D retroviruses; (b) have Mg. sup. ++ --dependent reverse transcriptase activity; (c) induce human multinucleated cells without immortalizing the cells; (d) are replicable in HUT-78 human T cells; and (e) induce viral protein(s) in HUT-78 that binds to Ig from AIDS patients. The infected HUT-78 cells and immunogenic polypeptides derived from the viruses are useful for diagnosing AIDS.

5565549, Oct 15, 1996

Sep 17, 1993

8/122221

Jay A. Levy - San Francisco CA
Carl E. Mackewicz - San Francisco CA

The Regents Of The University Of California - Oakland CA

C07K 100, A61K 3526, G01N 3353, G01N 33567

530351

A protein secreted by peripheral blood mononuclear cells and specifically from CD8. sup. + lyphocytes is purified and characterized here and designated CD8. sup. + cell antiviral factor (CAF). The CAF is lipid free, has a molecular weight of less than 30,000 and has been found to inhibit the replication of retroviruses and in particular to inhibit the replication of HIV-1, HIV-2, and SIV. CAF can be used to inhibit viral RNA transcription which inhibits viral replication. Accordingly, CAF can be used to treat patients infected with retroviruses. The CAF can also generate antibodies which can be used to create assay reagents for detecting CAF in a body fluid and on the surface of CD8. sup. + cells to determine the condition of an HIV infected individual.

5580769, Dec 3, 1996

Sep 16, 1994

8/307179

Jay A. Levy - San Francisco CA
Carl E. Mackewicz - San Francisco CA

The Regents of The University of California - Oakland CA

C12N 1500, G01N 3353, C07K 100, A61K 3900

4351723

A protein secreted by peripheral blood mononuclear specifically from CD8. sup. + lymphocytes is purified and characterized here and designated CD8. sup. + cell antiviral factor (CAF). The CAF is lipid free and has been found to inhibit the replication of retroviruses and in particular to inhibit the replication of HIV-1, HIV-2, and SIV. CAF can be used to inhibit viral RNA transcription which inhibits viral replication. Accordingly, CAF can be used to treat patients infected with retroviruses. The CAF can also generate antibodies which can be used to create assay devices for detecting CAF in a body fluid and on the surface of CD8. sup. + cells to determine the condition of an HIV infected individual.

4716102, Dec 29, 1987

Aug 15, 1984

6/641167

Jay A. Levy - San Francisco CA

Regents of the University of California - Berkeley CA

G01N 33543, C12N 700, C12N 500

435 5

A newly discovered family of AIDS-associated viruses, designated ARV, is described. The viruses were isolated from AIDS patients from San Francisco and (a) are type D retroviruses; (b) have Mg. sup. ++ -dependent reverse transcriptase activity; (c) induce human multinucleated cells without immortalizing the cells; (d) are replicable in HUT-78 human T cells; and (e) induce viral protein(s) in HUT-78 that binds to Ig from AIDS patients. The infected HUT-78 cells and immunogenic polypeptides derived from the viruses are useful for diagnosing AIDS.

5426028, Jun 20, 1995

Nov 4, 1991

7/787389

Jay A. Levy - San Francisco CA
Alan L. Landay - Oak Park IL

Rush-Presbyterian-St. Lukes Medical Center - Chicago IL
The Regents of The University of California - Alameda CA

G01N 33577

435 724

The subject invention permits diagnosis of chronic fatigue syndrome (CFS) by analyzing peripheral blood mononuclear cell subset populations and activation markers. A positive diagnosis for CFS is associated with an increase in the percentage of CD8+ cells showing CD38 or HLA-DR cell markers or a decrease in CD11b markers in CD8+ cells. The analysis is preferably performed using fluorochrome-labelled monoclonal antibodies specific for a determinant of the above subset cells and activation markers.

5538856, Jul 23, 1996

Mar 7, 1995

8/399774

Jay A. Levy - San Francisco CA
Alan L. Landay - Oak Park IL

The Regents of the University of California - Oakland CA

G01N 33577

435 724

The subject invention permits diagnosis of chronic fatigue syndrome (CFS) by analyzing peripheral blood mononuclear cell subset populations and activation markers. A positive diagnosis for CFS is associated with an increase in the percentage of CD8+ cells showing CD38 or HLA-DR cell markers or a decrease in CD11b markers in CD8+ cells. The analysis is preferably performed using fluorochrome-labelled monoclonal antibodies specific for a determinant of the above subset cells and activation markers.

5736328, Apr 7, 1998

May 31, 1995

8/443892

Jay A. Levy - San Francisco CA

Regents of the University of California - Alameda CA

C12Q 170, C12Q 168, C07H 2102, C07H 2104, C07H 2100

435 6

A newly discovered family of AIDS-associated viruses, designated ARV, is described. The viruses were isolated from AIDS patients from San Francisco and (a) are type D retroviruses; (b) have Mg. sup. ++ -dependent reverse transcriptase activity; (c) induce human multinucleated cells without immortalizing the cells; (d) are replicable in HUT-78 human T cells; and (e) induce viral protein(s) in HUT-78 that binds to Ig from AIDS patients. The infected HUT-78 cells and immunogenic polypeptides derived from the viruses are useful for diagnosing AIDS.