Inventors:
Vijay K. Kuchroo - Newton Center MA, US
Laurent Monney - Cambridge MA, US
Jason L. Gaglia - Boston MA, US
Edward A. Greenfield - Stoughton MA, US
Gordon J. Freeman - Brookline MA, US
Hanspeter Waldner - Cambridge MA, US
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
Dana-Farber Cancer Institute, Inc. - Boston MA
International Classification:
A61K 39/395
US Classification:
4241301, 4241391, 4241371
Abstract:
The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods useful for promoting or inhibiting antigen-presenting cell (APC) activation. The invention is related to discovery of functional characteristics of TIM-3, a molecule that is preferentially expressed on the surface of Th1 cells. The methods are useful for treating disorders including cancer, infectious disease, allergy, asthma, and autoimmune disease.