Inventors:
BRIAN CLEM - LOUISVILLE KY, US
SUCHETA TELANG - LOUISVILLE KY, US
JOHN TRENT - LOUISVILLE KY, US
JASON CHESNEY - LOUISVILLE KY, US
POORAN CHAND - BIRMINGHAM AL, US
GILLES TAPOLSKY - LOUISVILLE KY, US
International Classification:
A61K 31/4709, A61K 31/426, A61K 31/428, A61K 31/427, A61K 31/4196, A61K 31/4166, A61K 31/216, A61K 31/24, A61K 31/165, C07D 401/04, C07D 401/12, C07D 417/12, C07D 277/24, C07D 249/12, C07D 233/78, C07C 323/62, C07C 69/736, C07C 235/34, A61P 35/00, G06G 7/58
US Classification:
514314, 514365, 514367, 514371, 514384, 514389, 514391, 514510, 514534, 514543, 514622, 546167, 546171, 548178, 548195, 548204, 5482644, 5483167, 560 9, 560 61, 564182, 703 11
Abstract:
Small molecule choline kinase inhibitors, pharmaceutical compositions thereof, and screening methods for identifying and evaluating choline kinase inhibitors are provided. Safe and effective methods for treating subjects suffering from a disorder or disease characterized by neoplastic cell proliferation employing the choline kinase inhibitors are also provided.