Inventors:
Jasbir SINGH - Naperville IL, US
Mark E. GURNEY - Grand Rapids MI, US
Alex BURGIN - Kingston WA, US
Alexander KISELYOV - San Diego CA, US
Munagala RAO - Westmont IL, US
Timothy HAGEN - Lisle IL, US
Assignee:
DeCODE Genetics enf - Reykjavik
International Classification:
A61K 31/505, C07D 207/16, C07D 231/12, C07D 213/79, C07C 307/10, C07D 239/42, C07C 69/767, C07D 401/06, A61K 31/522, A61K 31/40, A61K 31/415, A61K 31/4412, A61K 31/165, A61K 31/235, A61K 31/4427, A61K 31/473, A61K 31/4748, A61K 31/445, A61K 31/355, A61K 31/122, A61P 9/00, A61P 9/10, A61P 35/00, A61P 11/06, A61P 11/00, A61P 19/08, A61P 13/10, C07D 473/18
US Classification:
424 941, 544276, 548532, 5483761, 546298, 564 79, 544297, 560 53, 546194, 51426337, 514423, 514406, 514350, 514600, 514275, 514543, 51421018, 51426331, 51426332, 514297, 514295, 514319, 514458, 514690
Abstract:
The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula Ia, Ib, Ic or Id:A particular embodiment is