JANE R SCHWEBKE
Medical Practice at Academy Cir, Pell City, AL
License number
Florida 111923
Issued Date
Jan 20, 2012
Effective Date
Mar 9, 2017
Expiration Date
Jan 31, 2016
Category
Health Care
Type
Medical Doctor
Address
Address
764 Academy Cir, Pell City, AL 35128
Professional information
Group B Streptococcal Phage Lysin
US Patent:
2004008, Apr 29, 2004
Filed:
Aug 28, 2003
Appl. No.:
10/650559
Inventors:
Jeffrey Engler - Birmingham AL, US
Jane Schwebke - Pell City AL, US
John Baker - Birmingham AL, US
David Pritchard - Indian Springs Village AL, US
Jane Schwebke - Pell City AL, US
John Baker - Birmingham AL, US
David Pritchard - Indian Springs Village AL, US
International Classification:
A61K038/48, C12N009/48
US Classification:
424/094630, 435/212000
Abstract:
The present disclosure relates to the identification phage lysin from group B streptococci (GBS). The nucleic acid sequence and amino acid sequence of the GBS phage lysin is disclosed. The GBS phage lysin is a bifunctional protein comprising a glucosidase and an endopeptidease activity. The endopeptidase present in the GBS phage lysis has a substrate specificity that has not been previously reported. The bifunctional GBS phage lysin is effective against groups A, B, C, E and G streptococci. Also described are methods of using the GBS phage lysin for the prevention and treatment of bacterial infections.