DR. JAMES WENDELL LITTLE, M.D.
Medical Practice in Seattle, WA

2011004, Feb 17, 2011

Sep 21, 2010

12/887232

Jessica L. Foley - Seattle WA, US
Shahram Vaezy - Seattle WA, US
James W. Little - Seattle WA, US

University of Washington - Seattle WA

A61B 5/055, A61N 7/00

600411

A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.

2012031, Dec 13, 2012

Aug 20, 2012

13/590146

Jessica L. Foley - Seattle WA, US
Shahram Vaezy - Seattle WA, US
James W. Little - Seattle WA, US

University of Washington - Seattle WA

A61N 7/02, A61B 5/055, A61B 8/12, A61B 8/13

600411, 600439

A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.

8206299, Jun 26, 2012

Sep 21, 2010

12/887211

Jessica L. Foley - Seattle WA, US
Shahram Vaezy - Seattle WA, US
James W. Little - Seattle WA, US

University of Washington - Seattle WA

A61B 8/00, A61H 1/00

600439, 601 2

A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.

7510536, Mar 31, 2009

Dec 16, 2004

11/016701

Jessica L. Foley - Seattle WA, US
Shahram Vaezy - Seattle WA, US
James W. Little - Seattle WA, US

University of Washington - Seattle WA

A61H 1/00, A61B 8/00

601 2, 600439

A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic affect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversible a block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.

D374854, Oct 22, 1996

Sep 11, 1995

D/043692

James E. Little - Seattle WA
Narcisa T. Little - Seattle WA

D12400