JAMES VERSALOVIC, MD PHD
Medical Practice at Fannin St, Houston, TX

5691136, Nov 25, 1997

Aug 24, 1993

8/111077

James R. Lupski - Houston TX
James Versalovic - Houston TX
Thearith Koeuth - Houston TX

Baylor College of Medicine - Houston TX

C12Q 168, C12P 1934

435 6

Oligonucleotide primers and methods for identifying strains of bacteria by genomic fingerprinting are described. The methods are applicable to a variety of samples. The testing procedure includes amplifying the bacterial DNA in the sample to be tested by adding a pair of outwardly-directed primers to the sample. The primers are capable of hybridizing to repetitive DNA sequences in the bacterial DNA and extending outwardly from one hybridizable repetitive sequence to another hybridizable repetitive sequence. After amplification the extension products are separated by size and the specific strain of bacteria is determined by measuring the pattern of sized extension products. The procedure to identify strains of bacteria by fingerprinting has a variety of uses including: identifying bacteria in infections, agriculture and horticulture plots, bioremediation, food monitoring, production monitoring and quality assurance and quality control.

5523217, Jun 4, 1996

May 25, 1994

8/248848

James R. Lupski - Houston TX
Thearith Koeuth - Houston TX
James Versalovic - Houston TX

Baylor College of Medicine - Houston TX

C12P 1934, C12Q 168, C07H 2104

435 912

Oligonucleotide primers and methods for identifying strains of bacteria by genomic fingerprinting are described. The methods are applicable to a variety of samples. The testing procedure includes amplifying the bacterial DNA in the sample to be tested by adding a pair of outwardly-directed primers to the sample. The primers are capable of hybridizing to repetitive DNA sequences in the bacterial DNA and extending outwardly from one hybridizable repetitive sequence to another hybridizable repetitive sequence. After amplification the extension products are separated by size and the specific strain of bacteria is determined by measuring the pattern of sized extension products. The procedure to identify strains of bacteria by fingerprinting has a variety of uses including: identifying bacteria in infections, agriculture and horticulture plots, bioremediation, food monitoring, production monitoring and quality assurance and quality control.

2004020, Oct 21, 2004

Jan 29, 2004

10/767317

James Versalovic - Houston TX, US
Jeremy Pena - Houston TX, US
Eamonn Connolly - Lidingo, SE

A61K035/00, C12N001/20

424/115000, 435/252900

In the present invention, lactic acid bacteria produce soluble factors (such as peptides or proteins) that block inflammatory responses in a mechanism that depends on G proteins and is post-transcriptional to effectively block protein production or secretion by cells.

2014006, Mar 6, 2014

Nov 7, 2013

14/074480

Delphine Saulnier - Bresse sur Grosne, FR
James Versalovic - Houston TX, US
Bo Mollstam - Lerum, SE

A61K 35/74

4352529

A specific method is provided of improving immunomodulatory properties of strains using growth media with a specific primary carbon source, including a method of increasing the anti-inflammatory effect of non-pathogenic anti-inflammatory bacterial strains, by the use of specific growth conditions.

2013014, Jun 13, 2013

Feb 13, 2013

13/765947

James Versalovic - Houston TX, US
Carissa Michelle Thomas - Houston TX, US
Eamonn Connolly - Lindingo, SE

A61K 35/74, A61K 31/4172

424 9345, 435 611, 4352529

A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an. active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production, of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions.

2013002, Jan 24, 2013

Jul 19, 2012

13/552686

James Versalovic - Houston TX, US
Carissa Michelle Thomas - Houston TX, US
Eamonn Connolly - Lindingo, SE

A61K 35/74, A61P 1/00, C12N 1/20, A61P 15/02, G01N 33/53, C12Q 1/04, A61P 29/00, A61P 1/04

424 9345, 435 792, 435 34, 4352529

A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions.

2011029, Dec 1, 2011

Feb 1, 2011

12/931482

Delphine Saulnier - Bresse sur Grosne, FR
James Versalovic - Houston TX, US
Bo Mollstam - Lerum, SE

A61K 39/02, A61K 9/48, A61K 35/74, A61P 37/02, A61P 29/00

424451, 4242341, 424 9345

A specific method is provided of improving immunomodulatory properties of strains using growth media with a specific primary carbon source, including a method of increasing the anti-inflammatory effect of non-pathogenic anti-inflammatory bacterial strains, by the use of specific growth conditions.