JAMES V. WINKLER, MD
Osteopathic Medicine at Washington St, Denver, CO
License number
Colorado 19738
Category
Osteopathic Medicine
Type
General Practice
Address
Address
800 Washington St, Denver, CO 80203
Phone
(303) 300-2200
Personal information
See more information about JAMES V. WINKLER at radaris.comName
Address
Phone
4545 W Ponds Dr, Littleton, CO 80123
5210 Barrett Rd, Colorado Spgs, CO 80926
980 W 7Th Avenue Dr, Broomfield, CO 80020
2520 15Th Avenue Ct, Greeley, CO 80631
Professional information
Diagnosis And Monitoring Of Inflammation, Ischemia And Appendicitis
US Patent:
2013017, Jul 4, 2013
Filed:
Dec 30, 2011
Appl. No.:
13/341608
Inventors:
David Bar-Or - Englewood CO, US
Raphael Bar-Or - Denver CO, US
James V. Winkler - Denver CO, US
Richard L. Yukl - Denver CO, US
Raphael Bar-Or - Denver CO, US
James V. Winkler - Denver CO, US
Richard L. Yukl - Denver CO, US
International Classification:
G01N 33/68
US Classification:
435 792, 436501
Abstract:
The invention provides methods and kits for diagnosing and monitoring inflammation and/or ischemia in an animal. The methods comprise determining the quantity of a post-translationally modified protein, other than phosphorylated tau, present in a body fluid from an animal.The invention also provides an improved method and kits for diagnosing appendicitis in an animal. The method comprises determining the quantities of orthohydroxyhippuric acid and of a marker of general inflammation, such as a post-translationally modified protein, present in one or more body fluids of the animal.
Diagnosis And Monitoring Of Inflammation, Ischemia And Appendicitis
US Patent:
2004017, Sep 9, 2004
Filed:
Oct 2, 2003
Appl. No.:
10/680935
Inventors:
David Bar-Or - Englewood CO, US
Raphael Bar-Or - Denver CO, US
James Winkler - Denver CO, US
Richard Yukl - Denver CO, US
Raphael Bar-Or - Denver CO, US
James Winkler - Denver CO, US
Richard Yukl - Denver CO, US
International Classification:
G01N033/53
US Classification:
435/007100
Abstract:
The invention provides methods and kits for diagnosing and monitoring inflammation and/or ischemia in an animal. The methods comprise determining the quantity of a post-translationally modified protein, other than phosphorylated tau, present in a body fluid from an animal. The invention also provides an improved method and kits for diagnosing appendicitis in an animal. The method comprises determining the quantities of orthohydroxyhippuric acid and of a marker of general inflammation, such as a post-translationally modified protein, present in one or more body fluids of the animal.
Test For Rapid Evaluation Of Ischemic States And Kit
US Patent:
6492179, Dec 10, 2002
Filed:
Oct 2, 1998
Appl. No.:
09/165581
Inventors:
David Bar-Or - Englewood CO
Edward Lau - Boulder CO
James V. Winkler - Denver CO
Edward Lau - Boulder CO
James V. Winkler - Denver CO
Assignee:
Ischemia Techologies, Inc. - Arvada CO
International Classification:
G01N 3320
US Classification:
436 74, 436 63, 436 73, 436 86, 436 87, 436 88, 436171, 436903, 436904, 436518, 435 4, 435 71, 422 55, 422 66, 422 8205, 422 8209, 422 56, 422 58
Abstract:
The present invention relates to a rapid method for the detection of ischemic states and to a kit for use in such a method. Provided for is a rapid method of testing for the existence of and quantifying ischemia based upon method of detecting and quantifying the existence of an alteration of the serum protein albumin which occurs following an ischemic event; methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of circulating blood, analysis and measurement of the ability of serum albumin to bind exogenous cobalt, detection and measurement of the presence of copper in a purified albumin sample and use of an immunological assay sepcific to the alterated form of serum albumin which occurs following an ischemic event. Also taught by the present invention is the use of the compound Asp-Ala-His-Lys-R, wherein R is any chemical group capable of being detected when bound to any compound capable of binding to the N-terminus of naturally occurring human albumin (including no additional chemical group), for detection and quantification of an ischemic event.
Tests For The Rapid Evaluation Of Ischemic States And Kits
US Patent:
2003021, Nov 20, 2003
Filed:
Apr 15, 2003
Appl. No.:
10/414386
Inventors:
David Bar-Or - Englewood CO, US
Edward Lau - Boulder CO, US
James Winkler - Denver CO, US
Edward Lau - Boulder CO, US
James Winkler - Denver CO, US
Assignee:
Ischemia Technologies, Inc. - Arvada CO
International Classification:
G01N033/20, C07K014/675
US Classification:
436/074000, 530/363000
Abstract:
The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method of testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an alteration of the serum protein albumin which occurs following an ischemic event; methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of circulating albumin, analysis and measurement of the ability of serum albumin to bind exogenous cobalt, detection and measurement of the presence of endogenous copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following an ischemic event. Also taught by the present invention is the detection and measurement of an ischemic event by measuring albumin N-terminal derivatives that arise following an ischemic event, including truncated albumin species lacking one to four N-terminal amino acids or albumin with an acetylated N-terminal Asp residue.
Tests For The Rapid Evaluation Of Ischemic States And Kits
US Patent:
2003021, Nov 20, 2003
Filed:
Apr 15, 2003
Appl. No.:
10/413832
Inventors:
David Bar-Or - Englewood CO, US
Edward Lau - Boulder CO, US
James Winkler - Denver CO, US
Edward Lau - Boulder CO, US
James Winkler - Denver CO, US
Assignee:
ISCHEMIA TECHNOLOGIES, INC.
International Classification:
G01N033/03
US Classification:
422/061000
Abstract:
The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method of testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an alteration of the serum protein albumin which occurs following an ischemic event; methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of circulating albumin, analysis and measurement of the ability of serum albumin to bind exogenous cobalt, detection and measurement of the presence of endogenous copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following an ischemic event. Also taught by the present invention is the detection and measurement of an ischemic event by measuring albumin N-terminal derivatives that arise following an ischemic event, including truncated albumin species lacking one to four N-terminal amino acids or albumin with an acetylated N-terminal Asp residue.
Test For The Rapid Evaluation Of Ischemic States And Kits
US Patent:
2005014, Jun 30, 2005
Filed:
Jan 12, 2005
Appl. No.:
11/033766
Inventors:
David Bar-Or - Englewood CO, US
Edward Lau - Boulder CO, US
James Winkler - Denver CO, US
Gary Fagan - Broomfield CO, US
Hollie Wayment - Elizabeth CO, US
Edward Lau - Boulder CO, US
James Winkler - Denver CO, US
Gary Fagan - Broomfield CO, US
Hollie Wayment - Elizabeth CO, US
International Classification:
G01N033/53, C07K014/765
US Classification:
435007100, 530363000
Abstract:
The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method of testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an alteration of the serum protein albumin which occurs following an ischemic event; methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of circulating albumin, analysis and measurement of the ability of serum albumin to bind exogenous cobalt, detection and measurement of the presence of endogenous copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following an ischemic event. Also taught by the present invention is the detection and measurement of an ischemic event by measuring albumin N-terminal derivatives that arise following an ischemic event, including truncated albumin species lacking one to four N-terminal amino acids or albumin with an acetylated N-terminal Asp residue.
Tests For The Rapid Evaluation Of Ischemic States And Kits
US Patent:
7449338, Nov 11, 2008
Filed:
Dec 13, 2002
Appl. No.:
10/319263
Inventors:
David Bar-Or - Englewood CO, US
Edward Lau - Boulder CO, US
James V. Winkler - Denver CO, US
Gary Fagan - Broomfield CO, US
Hollie Wayment - Elizabeth CO, US
Edward Lau - Boulder CO, US
James V. Winkler - Denver CO, US
Gary Fagan - Broomfield CO, US
Hollie Wayment - Elizabeth CO, US
Assignee:
Ischemia Technologies, Inc. - Waltham MA
International Classification:
G01N 33/48
US Classification:
436 63, 436182
Abstract:
The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method of testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an alteration of the serum protein albumin which occurs following an ischemic event; methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of circulating albumin, analysis and measurement of the ability of serum albumin to bind exogenous cobalt, detection and measurement of the presence of endogenous copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following an ischemic event. Also taught by the present invention is the detection and measurement of an ischemic event by measuring albumin N-terminal derivatives that arise following an ischemic event, including truncated albumin species lacking one to four N-terminal amino acids or albumin with an acetylated N-terminal Asp residue.
Metal-Binding Compounds And Uses Therefor
US Patent:
8017728, Sep 13, 2011
Filed:
Nov 2, 2009
Appl. No.:
12/610508
Inventors:
David Bar-Or - Englewood CO, US
C. Gerald Curtis - Cardiff, GB
Edward Lau - Boulder CO, US
Nagaraja K. R. Rao - Cardiff, GB
James V. Winkler - Denver CO, US
Wannell M. Crook - Castle Rock CO, US
C. Gerald Curtis - Cardiff, GB
Edward Lau - Boulder CO, US
Nagaraja K. R. Rao - Cardiff, GB
James V. Winkler - Denver CO, US
Wannell M. Crook - Castle Rock CO, US
International Classification:
C07K 7/00
US Classification:
530327, 514 215, 514 216, 530328
Abstract:
The invention provides a method of reducing the damage done by reactive oxygen species (ROS) in an animal. The invention also provides a method of reducing the concentration of a metal in an animal. These methods comprise administering to the animal an effective amount of a metal-binding compound as further described in the application. The invention further provides a method of reducing the damage done by ROS to a cell, a tissue or an organ that has been removed from an animal. This method comprising contacting the cell, tissue or organ with a solution or medium containing an effective amount of a metal-binding compound of the invention. The invention further provides novel metal-binding compounds, pharmaceutical compositions comprising the metal-binding compounds, and kits comprising a container holding a metal-binding compound of the invention.
Treatment Of Degenerative Joint Disease
US Patent:
2013009, Apr 11, 2013
Filed:
Nov 20, 2012
Appl. No.:
13/681618
Inventors:
James V. Winkler - Denver CO, US
Assignee:
AMPIO PHARMACEUTICALS, INC. - Greenwood Village CO
International Classification:
A61K 38/12, A61K 45/06
US Classification:
514 168
Abstract:
The invention provides a method of treating a degenerative joint disease. The method comprises administering an effective amount of a pharmaceutical composition comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP). The invention also provides a pharmaceutical product as well as a kit comprising DA-DKP.
Metal-Binding Compounds And Uses Therefor
US Patent:
2003013, Jul 10, 2003
Filed:
Jun 27, 2002
Appl. No.:
10/186168
Inventors:
David Bar-Or - Englewood CO, US
C. Curtis - Penylan, GB
Edward Lau - Boulder CO, US
Nagaraja Rao - Cardiff, GB
James Winkler - Denver CO, US
Wannell Crook - Castle Rock CO, US
C. Curtis - Penylan, GB
Edward Lau - Boulder CO, US
Nagaraja Rao - Cardiff, GB
James Winkler - Denver CO, US
Wannell Crook - Castle Rock CO, US
International Classification:
A61K038/10, A61K038/08
US Classification:
514/012000, 514/016000, 514/017000, 514/018000
Abstract:
The invention provides a method of reducing the damage done by reactive oxygen species (ROS) in an animal. The invention also provides a method of reducing the concentration of a metal in an animal. These methods comprise administering to the animal an effective amount of a metal-binding compound as further described in the application. The invention further provides a method of reducing the damage done by ROS to a cell, a tissue or an organ that has been removed from an animal. This method comprising contacting the cell, tissue or organ with a solution or medium containing an effective amount of a metal-binding compound of the invention. The invention further provides novel metal-binding compounds, pharmaceutical compositions comprising the metal-binding compounds, and kits comprising a container holding a metal-binding compound of the invention.