Inventors:
H. Warren - Charlestown MA, US
Judith Hellman - Brookline MA, US
James Kurnick - Winchester MA, US
International Classification:
A61K039/40, A61K039/02
Abstract:
The present invention relates to three outer membrane proteins conserved among Gram-negative bacteria, OmpA, PAL, and MLP. The invention provides vaccines and polypeptides useful for passive and active immunization against Gram-negative bacteria, as well as methods of preventing and treating Gram-negative sepsis.