Inventors:
Eric J. Verner - Foster City CA, US
Martin Sendzik - San Mateo CA, US
Chitra Baskaran - Foster City CA, US
Joseph J. Buggy - San Carlos CA, US
James Robinson - Sacramento CA, US
Assignee:
Pharmacyclics, Inc. - Sunnyvale CA
International Classification:
C07D 307/78, A61K 31/34
US Classification:
549467, 5142312, 5142521, 514350, 514383, 514396, 514406, 514419, 514423, 514443, 514469, 544166, 544336, 546229, 546298, 546336, 5482622, 5483351, 548491, 548537, 548560, 548565, 549 57, 549468
Abstract:
The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed.