Inventors:
Karol L. Nowakowski - Circle Pines MN, US
James E. Olson - Eagan MN, US
Edward T. Joseph - Inver Grove Heights MN, US
Daniel G. Ericson - Rochester MN, US
Assignee:
Closys Corporation - St. Paul MN
International Classification:
A61M 37/00, A61M 31/00, A61B 19/00, A61K 31/74, A61K 47/48
US Classification:
604 401, 604 501, 604 607, 604 609, 604 612, 604 615, 604 616, 604522, 604403, 424 7808, 424 7809, 424 781, 424 7817, 424 7826
Abstract:
A wound closure apparatus and associated methods are provided which utilize blood fluid by activating the clotting cascade of blood fluid within a substantially enclosed sterile container then introducing the blood fluid to the wound site to complete clotting. An apparatus for providing ways of inhibiting anticoagulating agents and slowing fibrin clot degradation are also disclosed. Kits are also disclosed. The invention provides a clotting cascade initiation apparatus including a substantially enclosed sterile containment chamber within which an aliquot of blood fluid, either autologous or from donor sources, can be received and retained. In preferred embodiments, the sterile containment chamber further includes a heparin binding agent which will bind heparin and remove it from the blood fluid. In further embodiments, the containment chamber will also include a procoagulating agent, wherein a clotting cascade can be initiated when the blood fluid is accepted into the sterile containment chamber.