JAMES R KANE
Accountancy in Miami, FL

5037615, Aug 6, 1991

Oct 30, 1987

7/115153

James A. Kane - Miami FL

Cordis Corporation - Miami FL

G01N 2164, G01N 2177

422 8208

A fluorescence energy transfer indicator, a chemical sensor incorporating it, and a method for making it are provided, such being useful in medical, biological and industrial applications. The fluorescence energy transfer indicator includes a rigid spacer group that tethers together a fluorescent energy donor and a colorimetric indicator acceptor, the tethering being across a predetermined, known or determinable length in order to thereby tailor the indicator to the specific needs of the chemical sensor. The emission spectrum of the fluorescent energy donor overlaps with an absorbance spectrum of the colorimetric indicator acceptor, which undergoes a change in color or in color intensity as a function of the species being monitored or measured in accordance with parameters of the species such as pH, oxygen concentration, carbon dioxide concentration and the like.

4691708, Sep 8, 1987

Mar 10, 1986

6/838125

James Kane - Miami FL

Cordis Corporation - Dade FL

A61B 502

128667

The optical blood pressure catheter includes an elongated optical fiber located within the lumen of the catheter for transmitting light received at its proximal end to its distal end where the light is reflected from a mirror and the reflected light is received at the distal end and transmitted back to the proximal end thereof. A pressure transducer is located at the distal end of the catheter and includes a mirror which is spaced forwardly of the distal end of the optical fiber and is fixed in position relative thereto so as to receive and reflect light emitted from the distal end of the optical fiber and back into the distal end thereof. A side port is provided in the catheter housing adjacent its distal end and the side port is sealed with a pressure-responsive membrane responsive to pressure acting transversely thereof. The pressure-responsive memberane is coupled to the distal end of the optical fiber so that the distal end of the optical fiber is displaced in dependence upon pressure acting upon the membrane. The catheter is vented to atmospheric pressure permitting pressure readings greater or less than that of atmospheric pressure.

4785814, Nov 22, 1988

Aug 11, 1987

7/084301

James Kane - Miami FL

Cordis Corporation - Miami FL

A61B 500

128634

An optical probe is presented for use in measuring pH and oxygen content in blood in a blood vessel within a living body. An elongated flexible optical fiber means is provided which has a proximal end and a distal end. The distal end is adapted to be inserted into a blood vessel. A membrane is secured to the distal end of the optical fiber and receives light from the distal end of the fiber and returns light therethrough to the proximal end. The membrane is constructed of hydrophilic porous material containing a pH sensitive dye. A plurality of microspheres are embedded in and carried by the membrane. These microspheres are constructed hydrophobic material and each carries a fluorescent dye quenchable with oxygen. Consequently, when light is supplied to the proximal end of the optical fiber, it is conveyed to the membrane. This causes the pH sensitive dye to react and light is conveyed through the optical fiber having an intensity level indicative of the pH level in the blood.

5096671, Mar 17, 1992

Mar 15, 1989

7/324239

James A. Kane - Miami FL
Leonard Pinchuk - Miami FL

Cordis Corporation - Miami Lakes FL

G01N 2164, B05D 506

422 8207

Fiber optic chemical sensors and materials suitable for use in making same are provided. A charged hydrogel matrix membrane is suitable for affixing to the distal end portion and the like of an optical fiber waveguide, which charged hydrogel matrix has dispersed therewithin an oppositely charged ion exchange resin powder, which ion exchange powder has a colorimetric indicator component electrostatically coupled thereto, which colorimetric indicator component has the same charge as the charged hydrogel.

5152287, Oct 6, 1992

Aug 15, 1990

7/568275

James A. Kane - Miami FL

Cordis Corporation - Miami Lakes FL

A61B 500

128634

A chemical sensor matrix is provided for use in medical, biological and industrial applications. The gas sensor includes a cross-linked fluoropolymer matrix of a composite having a gas-sensitive indicator within the matrix. The composite includes a highly fluorinated monofunctional acrylate monomer and a multifunctional acrylate cross-linking agent. Gas-sensitive indicator components which are suitable for detecting gases such as oxygen, carbon dioxide and the like represent indicators suitable for incorporation into the cross-linked fluoropolymer matrix.