Inventors:
James Gorman - Natick MA, US
International Classification:
A61K 39/395, A61K 31/192, A61K 31/4168, A61K 31/4402, A61P 19/00, A61P 29/00, A61P 9/00, A61P 37/00, A61P 25/00, A61K 31/70, A61K 31/7105, A61K 38/02
US Classification:
424145100, 424130100, 424158100, 514002000, 514352000, 514401000, 514044000, 514054000, 514570000
Abstract:
Methods and materials are provided for induction-maintenance regimens of targeted anti-inflammatory therapies (TATs) for treatment of a variety of diseases and disorders. Preferred embodiments include administration of one or more TATs using an induction regimen comprising a lower dose per administration administered by a more invasive and/or more localized route, followed by administration of one or more TATS using a maintenance regimen, comprising a higher dose per administration administered by a less invasive and/or less localized route.