JAMES P DAILEY, M.D.
Medical Practice at State St, Erie, PA

2004008, May 6, 2004

Jul 17, 2003

10/620762

James Dailey - Erie PA, US
Judy Riffle - Blacksburg VA, US

A61K039/395, A61K031/56, A61K033/26, A61K009/14

424/489000, 424/145100, 424/646000, 514/171000

A method for targeted delivery of therapeutic agents within the eye is provided. Magnetic particles having associated therapeutic agents are injected into the eye, for example into the vitreous cavity. External magnets are then used move the particles to a desired position within the eye, for example, to the macula. The therapeutic agent that is delivered may be, for example, anti-VEGF (for the treatment of exudative macular degeneration) or a steroid (for the treatment of diabetic retinopathy).

6612311, Sep 2, 2003

Jul 16, 2002

10/195436

James P. Dailey - Erie PA 16505

A61B 1900

128898

A magnetic fluid is provided comprising a block copolymer stabilizer, magnetic particles and a fluid poly(alkylsiloxane) medium. The stabilizer comprises of cyano containing polysiloxane block which chelates magnetic metal particles, and at least one end block comprising polysiloxane blocks which are compatible with the medium.

6464968, Oct 15, 2002

Jun 29, 1999

09/342885

Judy S. Riffle - Blacksburg VA
Janice Paige Phillips - Blacksburg VA
James P. Dailey - Erie PA 16505

Virginia Tech Intellectual Properties, Inc. - Blacksburg VA
James P. Dailey - Erie PA

A61K 3174

424 7802, 424 7804, 424489, 424 93, 424 936

A magnetic fluid is provided comprising a block copolymer stabilizer, magnetic particles and a fluid polysiloxane medium. The stabilizer comprises an anchor block which chelates magnetic metal particles, and at least one end block which is compatible with the polysiloxane medium.

6547714, Apr 15, 2003

Sep 5, 2000

09/654636

James P. Dailey - Erie PA 16505

A61N 100

600 12, 600 15

The basic principle in repairing retinal detachments is closing the retinal break. An internal tamponade is a material suitable for intraocular use which is used to directly close a retinal break. A scleral buckle is a flexible device which can conform to and allow movement of the sclera. A new method to treat retinal detachment is to combine usage of a magnetic fluid tamponade with a magnetized flexible scleral buckle, which effects tamponade of the retina without interfering with vision. A substantial percentage of complicated retinal detachments currently go on to blindness despite multiple attempts at surgical intervention because of our inability to tamponade retinal breaks in certain locations. In a cross-sectional view of the eye, the retina and choroids sit on the sclera. Each break in the retina therefore sits on a specific location on the sclera.

6749844, Jun 15, 2004

Sep 3, 2002

10/232730

Judy S. Riffle - Blacksburg VA
Janice Paige Phillips - Blacksburg VA
James P. Dailey - Erie PA

Virginia Tech Intellectual Properties, Inc. - Blacksburg VA

A61K 3174

424 7808, 600420, 424 7802, 424 7804

A magnetic fluid is provided comprising a block copolymer stabilizer, magnetic particles and a fluid polysiloxane medium. The stabilizer comprises an anchor block which chelates magnetic metal particles, and at least one end block which is compatible with the polysiloxane medium.

2005020, Sep 15, 2005

Dec 14, 2004

11/010567

James Dailey - Erie PA, US
Judy Riffle - Blacksburg VA, US

A61F002/14, A61F009/007

600037000, 128898000, 623004100, 600012000

A magnetic polymer may be polymerized in living tissue. Retinal detachment may now be repaired without needing suturing, by using a magnetic fluid with a magnetic scleral buckle. The magnetic scleral buckle may be polymerized into place in the eye, rather than being preformed outside the eye as has been conventionally done. Magnetic systems formed internally may be used in other medical contexts, such as in drug delivery.

6135118, Oct 24, 2000

May 11, 1998

9/075698

James P. Dailey - Erie PA

A61B 1900, A61B 1752, A61N 200

128898

A method for treating retinal detachment in an eye is provided. The method includes inserting a magnetic fluid into the vitreal chamber of the eye and applying a magnetized scleral buckle to the eye to treat retinal detachment.