Inventors:
James Nataro - Charlottesville VA, US
Fernando Ruiz-Perez - Charlottesville VA, US
International Classification:
A61K 38/48, A61P 37/00, A61P 1/00, A61P 31/00, A61P 35/00, A61P 11/06, A61P 11/02, A61P 37/02, A61P 29/00, A61P 11/00
Abstract:
Provided are compositions and methods for treating inflammation due to an immune response. Non-limiting example compositions include class-2 SPATE proteins that are capable of cleaving proteins involved in an inflammatory immune response in a patient. Example compositions include at least one mucin-cleaving class-2 SPATE protein. Further example compositions include protein involved in intestinal colonization (Pic). Non-limiting example methods include methods of decreasing inflammation in a patient having inflammation and methods of perturbing immune response in a patient having a disease or condition in which an active immune response is attributable to a cause of the disease or condition, by administering to the patient a composition including at least one class-2 SPATE protein capable of cleaving proteins involved in an inflammatory immune response.