Inventors:
Louis Staudt - Silver Spring MD, US
George Wright - Rockville MD, US
Sandeep Dave - Washington DC, US
Bruce Tan - Baltimore MD, US
John Powell - Ijamsville MD, US
Wyndham Wilson - Washington DC, US
Elaine Jaffe - Great Falls VA, US
Wing Chan - Omaha NE, US
Timothy Greiner - Council Bluffs IA, US
Dennis Weisenburger - Elkhom NE, US
James Armitage - Omaha NE, US
Kai Fu - Omaha NE, US
Richard Fisher - Pittsford NY, US
Lisa Rimsza - Tucson AZ, US
Thomas Miller - Tucson AZ, US
Thomas Grogan - Tucson AZ, US
Elias Campo - Barcelona, ES
Silvia Bea - Sabadell, ES
Itziar Salaverria - Barcelona, ES
Armando Lopez-Guillermo - Barcelona, ES
Emili Montserrat - Barcelona, ES
Victor Moreno - Barcelona, ES
Andreas Zettl - Wurzburg, DE
German Ott - Wurzburg, DE
Hans-Konrad Muller-Hermelink - Wuerzburg, DE
Andreas Rosenwald - Wuerzburg, DE
Julie Vose - Omaha NE, US
Randy Gascoyne - North Vancouver, CA
Joseph Connors - Vancouver, CA
Erlend Smeland - Oslo, NO
Stein Kvaloy - Oslo, NO
Harald Holte - Oslo, NO
Jan Delabie - Oslo, NO
T. Andrew Lister - London, GB
International Classification:
C12Q 1/68, G06F 19/00
Abstract:
Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.