JAMES MORRIS ENGLAND
Medical Practice in Delaware
License number
Pennsylvania MD029599E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
Delaware
Media, PA 19063
Media, PA 19063
Personal information
See more information about JAMES MORRIS ENGLAND at radaris.comName
Address
Phone
4268 S State St, Camden Wyoming, DE 19934
102 Deer Run Rd, Townsend, DE 19734
Professional information
Dr. James M England, Media PA - MD (Doctor of Medicine)
Specialties:
Cytopathology
Address:
644 W Rose Tree Rd, Media 19063
Certifications:
Anatomic & Clinical Pathology, 1985, Cytopathology, 1989
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
Washington Center / School of Medicine
Graduated: 1982
Hospital Of The University Of Pennsylvania
Washington Center / School of Medicine
Graduated: 1982
Hospital Of The University Of Pennsylvania
Cellular Immunogens Comprising Cognate Proto-Oxogenes
US Patent:
6365151, Apr 2, 2002
Filed:
Oct 7, 1998
Appl. No.:
09/167322
Inventors:
Michael S Halpern - West Newton MA
James M England - Media PA
James M England - Media PA
Assignee:
Philadelphia Health and Educational Corporation - Philadelphia PA
International Classification:
A61K 3500
US Classification:
424 9321, 424 932, 435325, 4353201, 514 44
Abstract:
A cellular immunogen is provided for immunizing a host against the effects of the product of a target proto-oncogene, where the overexpression of the target proto-oncogene is associated with a malignancy. The cellular immunogen comprises host cells which have been transfected with at least one transgene construct comprising a transgene cognate to the target proto-oncogene and a strong promoter to drive the expression of the transgene in the transfected cells. The transgene encodes a gene product which induces host immunoreactivity to host self-determinants of the product of the target proto-oncogene gene. The transgene may comprise, for example, wild-type or mutant retroviral oncogene DNA cognate to the target proto-oncogene; or wild-type or mutant proto-oncogene DNA of a species different from the host species. The cellular immunogen may be prepared from biopsied host cells, e. g. skin fibroblasts, which are stably or transiently transfected with the transgene construct containing the cognate transgene.