DR. JAMES MICHAEL STEIN, D.M.D.
Dentist at Staniford St, Boston, MA
License number
Massachusetts DN16151
Category
Dentist
Type
Dentist
Address
Address
50 Staniford St FLOOR 10TH, Boston, MA 02114
Phone
(617) 227-6076
(617) 227-6037 (Fax)
(617) 227-6037 (Fax)
Professional information
Prevascularzed Polymeric Implants For Organ Transplantation
US Patent:
2002011, Aug 22, 2002
Filed:
Aug 29, 2001
Appl. No.:
09/942535
Inventors:
James Stein - West Roxbury MA, US
James Gilbert - Silver Spring MD, US
Donald Ingber - Boston MA, US
Robert Langer - Newton MA, US
Joseph Vacanti - Winchester MA, US
James Gilbert - Silver Spring MD, US
Donald Ingber - Boston MA, US
Robert Langer - Newton MA, US
Joseph Vacanti - Winchester MA, US
International Classification:
C12N011/08, A01N065/00, C12N011/00, A61F013/00
US Classification:
435/180000, 435/174000, 424/093700, 424/422000
Abstract:
A method is disclosed whereby cells having a desired function are seeded on and into biocompatible, biodegradable or non-degradable polymer scaffolding, previously implanted in a patient and infiltrated with blood vessels and connective tissue, to produce a functional organ equivalent. The resulting organoid is a chimera formed of parenchymal elements of the donated tissue and vascular and matrix elements of the host. The matrix should be a non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, should allow vascular and connective tissue ingrowth throughout approximately 10 to 90% of the matrix, and the injection of cells such as hepatocytes without damage to the cells or patient. The introduced cells attach to the connective tissue and are fed by the blood vessels. Immediately prior to polymer implantation portacaval shunts can be created to provide trophic stimulatory factors to the implants to enhance replication and function.