Inventors:
James Pluda - Hatfield PA, US
Stanley R. Frankel - Yardley PA, US
Victoria M. Richon - Wellesley MA, US
Steven Averbuch - North Wales PA, US
Judy H. Chiao - Berkeley Heights NJ, US
International Classification:
A61K 31/56, A61K 31/519
Abstract:
The present invention relates to a method of treating cancer in a subject in need thereof, by administering to a subject in need thereof a first amount of a histone deacetylase (HDAC) inhibitor or a pharmaceutically acceptable salt or hydrate thereof, and a second amount of an anti-cancer agent. The HDAC inhibitor and the anti-cancer agent may be administered to comprise therapeutically effective amounts. In various aspects, the effect of the HDAC inhibitor and the anti-cancer agent may be additive or synergistic.