Inventors:
Adnan M. M. Mjalli - Louisville KY
James Christopher Mason - San Diego CA
Kristen Lee Arienti - San Diego CA
Kevin Michael Short - Vista CA
Rachel Denise Anne Kimmich - Carlsbad CA
Todd Kevin Jones - Solana Beach CA
Assignee:
Ontogen Corporation - Carlsbad CA
International Classification:
A61K 3812, C07K 512
Abstract:
Compounds of formula A are disclosed: ##STR1## wherein R. sup. 1 is aralkyl or cycloalkyl; R. sup. 2 is cycloalkylmethyl, alkyl, or aralkyl;
R. sup. 3 is hydrogen, alkyl, substituted phenyl (including p-phenoxy-phenyl), or fluorene;
R. sup. 4 is hydrogen, alkyl, substituted phenyls (including 1-alkyl-4-carboxy-substituted phenyls), alkyl carboxylic acids;
R. sup. 5 is hydrogen or R. sup. 1 and R. sup. 5 taken together forming a tetrahydroisoquinoline ring or a piperidine ring.
These compounds exhibit inhibitory action against fructose-1,6-bisphosphatase (FBPase) and are indicated in the treatment or management of Type II diabetes.