JAMES M OLSON
Medical Practice at Sand Point Way, Seattle, WA

2012009, Apr 19, 2012

Dec 19, 2011

13/330044

S. Bahram Bahrami - Emeryville CA, US
Mandana Veiseh - Emeryville CA, US
James Olson - Seattle WA, US

C40B 30/06

506 10

A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.

2012008, Apr 12, 2012

Dec 19, 2011

13/330022

S. Bahram Bahrami - Emeryville CA, US
Mandana Veiseh - Emeryville CA, US
James Olson - Seattle WA, US

A61M 5/00

604173

A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.

2012008, Apr 12, 2012

Dec 19, 2011

13/330106

S. Bahram BAHRAMI - Emeryville CA, US
Mandana Veiseh - Emeryville CA, US
James Olson - Seattle WA, US

A61K 49/00, C12Q 1/02, C40B 30/06

424 92, 506 10, 435 29

A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.

2008027, Nov 13, 2008

Aug 31, 2007

11/897721

Miqin Zhang - Bothell WA, US
Richard G. Ellenbogen - Seattle WA, US
Raymond W. Sze - Mclean VA, US
Omid Veiseh - Kirkland WA, US
James M. Olson - Seattle WA, US
Mandana Veiseh - Emeryville CA, US
Patrick Gabikian - Seattle WA, US

Washington, University of - Seattle WA
Fred Hutchinson Cancer Research Center - Seattle WA

A61K 49/00

424 96

A chlorotoxin conjugate detectable by fluorescence imaging that allows for intra-operative visualization of cancerous tissues, compositions that include the chlorotoxin conjugate, and methods for using the chlorotoxin conjugate.