Inventors:
James M. McKiernan - New York NY
Ihor S. Sawczuk - Tenafly NJ
Ralph Buttyan - New York NY
Neil H. Bander - Chappaqua NY
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
Cornell Research Foundation, Inc. - Ithaca NY
International Classification:
C12Q 168
Abstract:
This invention provides methods of: (a) diagnosing; (b) determining the stage of; and (c) monitoring the effect of a therapeutic intervention for a renal cell carcinoma in a human subject which comprises detecting the expression of the MN gene. In one embodiment, the method is directed to detection of the renal cell carcinoma known as clear cell carcinoma. In another embodiment, the method is used as a peripheral blood assay. In another embodiment, the method is a polymerase chain reaction assay for amplifying and detecting the presence of the cDNA molecule encoding the MN protein.