JAMES M HORTON, MD
Osteopathic Medicine at Kings Dr, Charlotte, NC

2011021, Sep 8, 2011

Jan 13, 2009

12/866939

Kenneth E. Gonsalves - Davidson NC, US
Michael J. Bosse - Charlotte NC, US
John Kent Ellington - Charlotte NC, US
Michael C. Hudson - Charlotte NC, US
James M. Horton - Charlotte NC, US

A61K 38/14, A61K 31/43, A61P 31/04, A61P 19/00, B65D 85/00, B82Y 5/00

514 29, 514 23, 514197, 2064595, 977773, 977906

Compositions that include antimicrobial agents and biodegradable delivery-vehicles adapted to enter a cell and release the antimicrobial agents in the cell as they biodegrade. Also provided are compositions that include first and second delivery vehicles including first and second antimicrobial agents, wherein the first delivery vehicles are adapted to release the first antimicrobial agents at a rate that differs from that at which the second delivery vehicles release the second antimicrobial agents, articles of manufacture that include one or more biodegradable delivery vehicles, and methods of making and using the compositions to treat intracellular and/or extracellular infections are disclosed.

6796949, Sep 28, 2004

Oct 7, 2002

10/149566

James M. Horton - Charlotte NC

Charlotte-Mecklenburg Hospital Authority - Charlotte NC

A61B 5103

600592, 600587, 128898, 2239

This invention provides a sock containing a coating material such as a coloring agent or dye, applied to at least a portion of the interior surface of the sock for sensing pressure points on a patients foot to which the sock is fitted. The sock is placed on the patients foot to cover preferably the entire foot, but at least the bottom portion thereof. The sock is removed after being worn for a period of time, and in those areas of the foot susceptible to pressure points, the coating material transfers from the interior of the sock and adheres to the foot in those points. The present invention is particularly applicable to a person having diabetic neuropathic feet wherein portions of the foot may be insensitive to pressure and therefore must be protected against pressure sores.

6918883, Jul 19, 2005

Jun 18, 2003

10/464413

James M. Horton - Charlotte NC, US
David Hinks - Apex NC, US
Ahmed El-Shafei - Raleigh NC, US

Cannon Research Institute of Carolinas Medical Center - Charlotte NC

A61B005/103

600592, 600300, 600587

The present invention provides a sock containing a coating applied to at least a portion of a surface of the sock for sensing pressure points on a patient's foot. The coating material comprises a pressure-sensitive film comprised of oxygen-sensitive photo luminescent probe molecules dispersed within a polymer matrix, and, optionally, an inorganic pigment. Areas of increased pressure can be detected by correspondence to areas on the film of increased fluorescence intensity. The coating material can also be comprised of a coloring agent or dye such that after the sock has been worn for a period of time, in those areas of the foot susceptible to pressure points, the coating material transfers from the interior of the sock and adheres to the foot in those points. The present invention is particularly applicable to persons having diabetic neuropathic feet wherein portions of the foot may be insensitive to pressure.