JAMES M CAMPBELL
Electrician in Weymouth, MA
License number
Massachusetts 19117
Issued Date
Dec 28, 1970
Expiration Date
Jul 31, 2019
Type
Journeyman Electrician
Address
Address
Weymouth, MA 02188
Personal information
See more information about JAMES M CAMPBELL at radaris.comName
Address
Phone
4 Barry Ave, Dudley, MA 01571
Professional information
See more information about JAMES M CAMPBELL at trustoria.com
Modulation Of Systemic Memory T Cell Trafficking
Modulation Of Systemic Memory T Cell Trafficking
US Patent:
2005016, Aug 4, 2005
Filed:
Feb 17, 2005
Appl. No.:
11/061052
Inventors:
Eugene Butcher - Portola Valley CA, US
James Campbell - Weymouth MA, US
Lijun Wu - Lexington MA, US
James Rottman - Sudbury MA, US
James Campbell - Weymouth MA, US
Lijun Wu - Lexington MA, US
James Rottman - Sudbury MA, US
International Classification:
G01N033/567, A61K039/395
US Classification:
424143100, 435007210
Abstract:
Methods are provided to specifically modulate the trafficking of systemic memory T cells, particularly CD4+ T cells, without affecting naive T cells or intestinal memory T cells. It is shown that systemic memory T cells, which are characterized as CD45Ra, and integrin α4β7, express high levels of CCR4. Ligands of CCR4, such as TARC or MDC, act as an adhesion trigger, wherein upon CCR4 binding, these cells undergo integrin-dependent arrest to the appropriate vascular receptor(s). This arrest acts to localize the cells at the target site. The methods of the invention manipulate this triggering, and CCR4 mediated chemotaxis, to affect the localization of T cells in targeted tissues. In one embodiment of the invention, the active agent is a CCR4 agonist, that acts to enhance T cell localization. In an alternative embodiment, the agent is an antagonist that blocks CCR4 biological activity. An advantage of the invention is the selectivity for systemic memory T cells, without affecting native T cells or intestinal memory T cells.