Inventors:
William Edward Bondinell - Wayne PA
James Francis Callahan - Philadelphia PA
William Francis Huffman - Malvern PA
Richard McCulloch Keenan - Malvern PA
Brian Walter Metcalf - Radnor PA
James Samanen - Phoenixville PA
Tobias Oregon Yellin - Villanova PA
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
C07D21373, A61K 3144
Abstract:
Compounds of the formula (I):
W--Z--(CR'R. sup. 10). sub. r --U--(CR'. sub. 2). sub. s --V--A (I)
wherein:
A is ##STR1## W is. sup. N ; Z is (CH. sub. 2). sub. 1-2 ;
U and V independently are present as CO, CR'. sub. 2, C(. dbd. CR'. sub. 2), S(O). sub. r, O, NR', CR'OR', CR'(OR")CR'. sub. 2, CR'. sub. 2 CR'(OR"), C(O)CR'. sub. 2, CR'. sub. 2 C(O), CONR', NR'CO, OC(O), C(O)O, C(S)O, OC(S), C(S)NR', NR'C(S), S(O). sub. r NR', NR'S(O). sub. r, N. dbd. N, NR'NR', NR'CR'. sub. 2, NR'CR'. sub. 2, CR'. sub. 2 O, OCR'. sub. 2, C. tbd. C, CR'. dbd. CR', or CR'(NR'R")C(O);
each r independently is 0 to 3;
s is 0 to 2;
each R' independently is H, C. sub. 1-4 alkyl, C. sub. 3-7 cycloalky-C. sub.